| Project/Area Number |
25460926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
Ohashi Shinya 京都大学, 医学(系)研究科(研究院), 助教 (20435556)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 食道癌 / EGFR阻害剤 / 分化誘導 / EGFRシグナル阻害 / 上皮系癌細胞 / 間葉系癌細胞 / 治療抵抗性 / 食道扁平上皮癌 / 細胞分化 / EGFR阻害 / 抗がん剤耐性 |
|---|
| Outline of Final Research Achievements |
Cytotoxic and anti-tumor effects of EGFR inhibitors on human (esophageal squamous cell carcinoma) ESCC cells (TE1, TE5, TE8, TE11R, and HCE4) as well as transformed esophageal epithelial cells (T-Epi, T-Mes) were investigated. EGFR inhibitors showed cytotoxic and anti-tumor effect on epithelial-like cells (TE1, TE5, TE11, TE11R, and T-Epi) in accompany with increased expression of cell differentiation markers, but not on mesenchymal-like cells (TE8, HCE4, and T-Mes). EGFR inhibitors are considered to be effective for epithelial-like ESCC cells through the induction of cell differentiation.
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