The establishment of treatment for pancreatic cancer using miRNA associated with stem cells related pancreatic cancer.
Project/Area Number |
25461020
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Tohoku University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HAMADA Shin 東北大学, 医学系研究科, 助教 (20451560)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 膵癌 / EUS-FNA / miRNA |
Outline of Final Research Achievements |
We have obtained the histological sample of pancreatic cancer using Endoscopic ultrasonography-fine needle aspiration (EUS-FNA) and continued to make the genetic profile. The evaluation of expression of the marker associated with stem cells related pancreatic cancer was performed. However, we could not detect these markers. Since one of the causes not to detect these markers is that the amount of histological sample by EUS-FNA is very small, we continue to evaluate these markers using the histological samples acquired by operation. Furthermore, sensitivity test of anti cancer drug for pancreatic caner using histological sample acquired by EUS-FNA has been continued. We have compared the clinical information and surgical stage. The cell lines of resistance for anti-cancer drug were used for checking the genetic profile.
|
Report
(4 results)
Research Products
(16 results)
-
[Journal Article] Risk factors for recurrent biliary obstruction following placement of self-expandable metallic stents in patients with malignant perihilar biliary stricture.2016
Author(s)
Miura S, Kanno A, Masamune A, Hamada S, Hongou S, Yoshida N, Nakano E, Takikawa T, Kume K, Kikuta K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T.
-
Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Diagnosis of autoimmune pancreatitis by endoscopic ultrasonography -guided fine-needle aspiration using a 22-gauge needle: a prospective multicenter study2016
Author(s)
Atsushi Kanno, Atsushi Masamune, Fumiyoshi Fujishima, Takuji Iwashita, Yuzo Kodama, Akio Katanuma, Hirotaka Ohara, Masayuki Kitano, Hiroyuki Inoue, Takao Itoi, Nobumasa Mizuno, Hiroyuki Miyakawa, Rintaro Mikata, Atsushi Irisawa, Satoko Sato, Kenji Notohara, Tooru Shimosegawa
-
Journal Title
Gastrointestical Ensosc
Volume: 印刷中
Related Report
Acknowledgement Compliant
-
[Journal Article] Clinicopathological Features of Type 2 Autoimmune Pancreatitis in Japan: Results of a Multicenter Survey.2015
Author(s)
Notohara K, Nishimori I, Mizuno N, Okazaki K, Ito T, Kawa S, Egawa S, Kihara Y, Kanno A, Masamune A, Shimosegawa T.
-
Journal Title
Pancreas
Volume: 44
Issue: 7
Pages: 1072-7
DOI
Related Report
Peer Reviewed
-
[Journal Article] IgG4-unrelated type 1 autoimmune pancreatitis.2015
Author(s)
Nakano E, Kanno A, Masamune A, Yoshida N, Hongo S, Miura S, Takikawa T, Hamada S, Kume K, Kikuta K, Hirota M, Nakayama K, Fujishima F, Shimosegawa T.
-
Journal Title
World J Gastroenterol.
Volume: 21
Issue: 33
Pages: 9808-16
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture.2015
Author(s)
Miura S, Kanno A, Masamune A, Hamada S, Takikawa T, Nakano E, Yoshida N, Hongo S, Kikuta K, Kume K, Hirota M, Yoshida H, Katayose Y, Uuno M, Shimosegawa T.
-
Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Sudden disappearance of the blood flow in a case of pancreatic acinar cell carcinoma.2014
Author(s)
Kanno A, Masamune A, Hamada S, Kikuta K, Kume K, Hirota M, Shima K, Okada T, Motoi F, Fujishima F, Ishida K, Unno M, Shimosegawa T.
-
Journal Title
Intern Med.
Volume: 53
Pages: 2589-93
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification.2014
Author(s)
Unno J, Kanno A, Masamune A, Kasajima A, Fujishima F, Ishida K, Hamada S, Kume K, Kikuta K, Hirota M, Motoi F, Unno M, Shimosegawa T.
-
Journal Title
Scand J Gastroenterol.
Volume: 49
Pages: 1367-74
Related Report
Peer Reviewed
-
-
[Journal Article] Establishment of a Serum IgG4 Cut-off Value for the Differential Diagnosis of IgG4-related Sclerosing Cholangitis- A Japanese Cohort.2013
Author(s)
Ohara H, Nakazawa T, Kawa S, Kamisawa T, Shimosegawa T, Uchida K, Hirano K, Nishino T, Hamano H, Kanno A, Notohara K, Hasebe O, Muraki T, Ishida E, Naitoh I, Okazaki K.
-
Journal Title
J Gastroenterol Hepatol
Volume: 28
Issue: 7
Pages: 1247-51
DOI
Related Report
Peer Reviewed
-
[Journal Article] Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis: The JENIPaN study.2013
Author(s)
Yasuda I, Nakashima M, Iwai T, Isayama H, Itoi T, Hisai H, Inoue H, Kato H, Kanno A, Kubota K, Irisawa A, Igarashi H, Okabe Y, Kitano M, Kawakami H, Hayashi T, Mukai T, Sata N, Kida M, Shimosegawa T
-
Journal Title
Endoscopy.
Volume: 45
Issue: 08
Pages: 627-634
DOI
Related Report
Peer Reviewed
-
[Journal Article] Pancreati duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy2013
Author(s)
Takikawa T, Kanno A, Masamune A, Hamada S, Nakano E, Miura S, Ariga H, Unno J, Kume K, Kikuta K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T
-
Journal Title
World J Gastroenterol
Volume: 19
Issue: 31
Pages: 5182-5186
DOI
Related Report
Peer Reviewed
-
[Presentation] Diagnosis of autoimmune pancreatitis by endoscopic ultrasonography -guided fine-needle aspiration using a 22-gauge needle: a prospective multicenter study2015
Author(s)
Atsushi Kanno, Atsushi Masamune, Fumiyoshi Fujishima, Takuji Iwashita, Yuzo Kodama, Akio Katanuma, Hirotaka Ohara, Masayuki Kitano, Hiroyuki Inoue, Takao Itoi, Nobumasa Mizuno, Hiroyuki Miyakawa, Rintaro Mikata, Atsushi Irisawa, Satoko Sato, Kenji Notohara, Tooru Shimosegawa
Organizer
DDW 2015
Place of Presentation
Washington DC,USA
Year and Date
2015-05-16
Related Report
Int'l Joint Research
-
-
[Presentation] EUS-FNA is useful to diagnose pancreatic neuroendocrine tumors based on the World Health Organization classification2014
Author(s)
Atsushi Kanno, MD, PhD,1 Jun Unno, MD, PhD,1 Atsushi Masamune, MD, PhD,1Atsuko Kasajima, MD, PhD,2 Fumiyoshi Fujishima, MD, PhD,2 Kazuyuki Ishida, MD, PhD,3 Tooru Shimosegawa, MD, PhD1
Organizer
2014 DDW ASGE
Place of Presentation
Chicago, USA
Year and Date
2014-05-03 – 2014-05-06
Related Report