microRNA released from adipose cells regulate vascular remodeling

• Project/Area Number: 25461131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokushima
• Principal Investigator: YAGI Shusuke 徳島大学, 大学院医歯薬学研究部, 助教 (00507650)
• Co-Investigator(Kenkyū-buntansha): SATA Masataka 徳島大学, 大学院医歯薬学研究部, 教授 (80345214) ; ISHIDA Masayoshi 琉球大学, 医学(系)研究科(研究院), 助教 (50643251)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: マイクロRNA / 脂肪細胞 / ﾏｲｸﾛRNA / 平滑筋細胞

Outline of Final Research Achievements

Perivascular fat produces various vasoactive substances and exerts important rolls in vascular chronic inflammation and vascular remodeling.It is known that microRNAs released from cells enter another cells to regulate gene expression. In this study, we showed that miR-100 released from adipose cells regulates mTOR in smooth muscle cells, indicating that miRNA regulates cell proliferation.

Research Products

• [Journal Article] Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome (2015)
  • Author(s): Yagi S, Aihara K, Fukuda D, Takashima A, Bando M, Hara T, Nishimoto S, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: Nut J Volume: 14 Issue: 1 Pages: 111-111
  • DOI: 10.1186/s12937-015-0102-4
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Docosahexaenoic Acid on the Endothelial Function in Patients with Coronary Artery Disease (2015)
  • Author(s): Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 5 Pages: 447-454
  • DOI: 10.5551/jat.26914
  • NAID: 130004700298
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Predictive Factors for Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus. (2015)
  • Author(s): Yagi S, Aihara K, Akaike M, Fukuda D, Salim HM, Ishida M, Matsuura T, Ise T, Yamaguchi K, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Matsumoto T, Sata M.
  • Journal Title: Diabetes Metab J. Volume: 39 Issue: 4 Pages: 342-347
  • DOI: 10.4093/dmj.2015.39.4.342
  • Peer Reviewed / Open Access
• [Journal Article] Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease. (2015)
  • Author(s): Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: J Atheroscler Thromb. Volume: 22 Pages: 447-454
  • NAID: 130004700298
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability (2015)
  • Author(s): Soeki T, Yamaguchi K, Niki T, Uematsu E, Bando S, Matsuura T, Ise T, Kenya K, Hotchi J, Tobiume T, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: Circulation Journal Volume: 79 Issue: 2 Pages: 413-418
  • DOI: 10.1253/circj.CJ-14-0958
  • NAID: 130004927043
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice. (2015)
  • Author(s): Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: Atherosclerosis. Volume: 印刷中 Issue: 2 Pages: 639-646
  • DOI: 10.1016/j.atherosclerosis.2015.03.023
  • Peer Reviewed / Open Access
• [Journal Article] Serial Imaging Changes During Treatment of IgG4-related Disease with Multiple Pseudo Tumors. (2015)
  • Author(s): Kusunose K, Hotchi J, Takagawa Y, Nishio S, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: Circulation Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Impact of indoxyl sulfate, a uremic toxin, on non-culprit coronary plaque composition assessed by integrated backscatter intravascular ultrasound. (2015)
  • Author(s): Yamazaki H, Yamaguchi K, Soeki T, Wakatsuki T, Niki T, Taketani Y, Kitaoka A, Kusunose K, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Sata M.
  • Journal Title: Circ J. Volume: 印刷中
  • NAID: 130005089366
  • Peer Reviewed / Open Access
• [Journal Article] Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men (2014)
  • Author(s): Yagi S, Kadota M, Aihara K, Nishikawa K, Hara T, Ise T, Ueda Y, Iwase T, Akaike M, Shimabukuro M, Katoh S, Sata M.
  • Journal Title: Diabetology & metabolic syndrome Volume: 6 Issue: 1 Pages: 27-27
  • DOI: 10.1186/1758-5996-6-27
  • Peer Reviewed / Open Access
• [Journal Article] Acute pulmonary thromboembolism from deep vein thrombosis induced by trauma to the popliteal vein with a tennis racket. (2014)
  • Author(s): Ise T, Iwase T, Masuda S, Yagi S, Akaike M, Nishio S, Niki T, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: JC Cases. Volume: 9 Issue: 4 Pages: 162-164
  • DOI: 10.1016/j.jccase.2014.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Pre-load stress echocardiography for predicting the prognosis in mild heart failure. (2014)
  • Author(s): Yamada H, Kusunose K, Nishio S, Bando M, Hotchi J, Hayashi S, Ise T, Yagi S, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: JACC Cardiovasc Imaging. Volume: 7 Issue: 7 Pages: 641-649
  • DOI: 10.1016/j.jcmg.2014.04.009
  • Peer Reviewed
• [Journal Article] High serum parathyroid hormone and calcium are risk factors for hypertension in Japanese patients. (2014)
  • Author(s): Yagi S, Aihara K, Kondo T, Endo I, Hotchi J, Ise T, Iwase T, Akaike M, Matsumoto T, Sata M.
  • Journal Title: Endocr J. Volume: 61 Pages: 727-733
  • NAID: 130004443979
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein. (2014)
  • Author(s): Takashima A, Ise T, Yagi S, Iwase T, Kimura S, Ueda Y, Nishikawa K, Ishii A, Niki T, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Katoh S, Akaike M, Sata M.
  • Journal Title: Circ J. Volume: 78 Pages: 2682-2687
  • NAID: 130004690797
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MicroRNA-378 Regulates Adiponectin Expression in Adipose Tissue: A New Plausible Mechanism. (2014)
  • Author(s): Ishida M, Shimabukuro M, Yagi S, Nishimoto S, Kozuka C, Fukuda D, Soeki T, Masuzaki H, Tsutsui M, Sata M
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e111537-e111537
  • DOI: 10.1371/journal.pone.0111537
  • Peer Reviewed / Open Access
• [Journal Article] Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease. (2014)
  • Author(s): Yagi S, Hara T, Ueno R, Aihara K, Fukuda D, Takashima A, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: Nutr J. Volume: 13 Pages: 1-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increase in serum triglyceride was associated with coronary plaque vulnerability in a patient with rheumatoid arthritis. (2014)
  • Author(s): Yagi S, Fujimura M, Akaike M, Aihara K, Iwase T, Tada M, Sumitomo-Ueda Y, Ise T, Yamaguchi K, Wakatsuki T, Matsumoto T, Sata M.
  • Journal Title: Journal of Cardiology Cases Volume: 10 Issue: 2 Pages: 54-57
  • DOI: 10.1016/j.jccase.2014.04.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension. (2014)
  • Author(s): Yagi S, Takashima A, Mitsugi M, Wada T, Hotchi J, Aihara K, Hara T, Ishida M, Fukuda D, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: Ther Clin Risk Manag. Volume: 11 Pages: 83-88
  • DOI: 10.2147/tcrm.s72299
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pentraxin 3 is a local inflammatory marker in atrial fibrillation (2013)
  • Author(s): Soeki T, Bando S, Uematsu E, Matsuura T, Niki T, Ise T, Kusunose K, Hotchi J, Ueda Y, Tomita N, Yamaguchi K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: Heart Vessels Volume: - Issue: 5 Pages: 27-27
  • DOI: 10.1007/s00380-013-0400-8
  • Peer Reviewed / Open Access
• [Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling (2013)
  • Author(s): Yoshida S, Aihara K, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama K, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
  • Journal Title: Circulation Volume: 128 Issue: 1 Pages: 60-71
  • DOI: 10.1161/circulationaha.113.001533
  • Peer Reviewed
• [Presentation] Post-transcriptional regulation of adiponectin by microRNA-378 in adipose tissue: a novel mechanism for hypoadiponectinemia. (2014)
  • Author(s): Shimabukuro M, Ishida M, Yagi S, Fukuda D, Soeki T, Sata M.
  • Organizer: ESC Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-06-20 – 2014-06-24