| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Encapsulating peritoneal sclerosis (EPS) is one of the most serious complications of long-term peritoneal dialysis. The purpose of this study was to clarify the roles of T helper (Th) (Th1/Th2/Th17) cells in the progression of peritoneum fibrosis (PF) in EPS. T-bet, GATA-3, and RORγt are Th1, Th2, and Th17 lineage commitment transcription factors, respectively. In this study, Th1-biased (T-bet transgenic (Tg)) mice, Th2-biased (GATA-3 Tg) mice, and Th17-biased (RORγt Tg), and wild-type mice were administered chlorhexidine gluconate (CG) intraperitoneally. CG-injected GATA-3 Tg mice developed marked PF. In contrast, CG-injected T-bet Tg mice only developed mild PF. Cytokines analysis in peritoneal fluid showed that IFN-γ was significantly increased in CG-injected T-bet Tg mice. Moreover, intraperitoneal administration of IFN-γ improved PF in GC-injected wild-type mice. Our results suggest that the regulation of Th cells and cyotokines may alleviate the severity of experimental PF.
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