The role of clock genes in non-dipper hypertension
| Project/Area Number |
25461248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
Nakashima Ayumu 広島大学, 原爆放射線医科学研究所, 特任助教 (40448262)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI YUKIHITO 広島大学, 原爆放射線医科学研究所, 教授 (40346490)
MASAKI TAKAO 広島大学病院, 教授 (30397913)
KAWAMOTO TAKESHI 広島大学, 社会産学連携室, 特任教授 (50224861)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 時計遺伝子 / 血圧 / DEC1 / CLOCK / 日内変動 / Na-K-ATPase / 概日リズム |
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| Outline of Final Research Achievements |
Tne Na-K-ATPase beta 1 (Atp1b1) mRNA and protein levels in mouse kidney, aorta and heart showed a circadian rhythm. Furthermore, Dec1-deficient mice showed enhanced Atp1b1 expression in these tissues and reduced blood pressure. In contrast, Clock-mutant mice showed reduced Atp1b1 expression and elevated blood pressure.
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Report
(4 results)
Research Products
(2 results)
