• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification and characterization of a novel protein that regulates adipogenesis and myogenesis

Research Project

Project/Area Number 25461354
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionOkayama University

Principal Investigator

EGUCHI JUN  岡山大学, 大学病院, 助教 (60616366)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsメタボリック症候群 / 肥満症 / 糖尿病 / メタボリックシンドローム / 肥満 / インスリン抵抗性 / 肥満サルコペニア
Outline of Final Research Achievements

Sarcopenic obesity refers to the co-presence of excess fat mass (obesity) and low muscle mass (sarcopenia). Sarcopenic obesity is a major risk factor for metabolic syndrome. Systemic insulin resistance is closely associated with the development of sarcopenic obesity. However, the pathophysiology of sarcopenic obesity in metabolic syndrome remains unclear. We identified Transmembrane protein 97 (Tmem97) as a novel regulator of adipogenesis and myogenesis by using lentiviral short hairpin RNA libraries targeting murine genomes. In the present study, we show that global Tmem97 deficient mice are protected from systemic insulin resistance associated with high fat feeding. These findings suggest that Tmem97 might play a key role in the development of sarcopenic obesity.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization2013

    • Author(s)
      Jun Eguchi, Xingxing Kong, Masafumi Tenta, Xun Wang, Sona Kang and Evan D. Rosen
    • Journal Title

      Diabetes

      Volume: 62 Issue: 10 Pages: 3394-3403

    • DOI

      10.2337/db12-1327

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi