The direct regulatory effects of melatonin on adrenocortical steroidogenesis and adrenal medullary catecholamine synthesis

• Project/Area Number: 25461388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Okayama University
• Principal Investigator: INAGAKI KENICHI 岡山大学, 大学病院, 講師 (80549882)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: メラトニン / 副腎 / 副腎皮質 / 副腎髄質

Outline of Final Research Achievements

Melatonin is known to be involved in the physiological circadian rhythm control and activities of various hormones and cytokines. In this study, we evaluated the effects of melatonin on the adrenocortical steroidogenesis and adrenal medullary catecholamine synthesis using the representative adrenocortical and adrenal medullary cell lines. The results of our study suggest the direct regulatory effect of melatonin on adrenal hormone production via the mutual interaction of intracellular signaling between melatonin and the adrenal local growth factors.

Research Products

• [Journal Article] Mutual effects of melatonin and activin on induction of aldosterone production by human adrenocortical cells. (2015)
  • Author(s): Hara T, Otsuka F, Tsukamoto-Yamauchi N, Inagaki K, Hosoya T, Nakamura E, Terasaka T, Komatsubara M, Makino H.
  • Journal Title: J Steroid Biochem Mol Biol. Volume: 152 Pages: 8-15
  • DOI: 10.1016/j.jsbmb.2015.04.012
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] カテコラミン合成系におけるメラトニンとBMP-4・ステロイドの作用とその機序 (2016)
  • Author(s): 小松原 基志、原 孝行、細谷 武史、寺坂 友博、山内 尚子、稲垣 兼一、和田 淳、大塚 文男
  • Organizer: 日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-04-21
• [Presentation] Melatonin regulates catecholamine synthesis by activating bone morphogenetic protein signaling and glucocorticoid actions (2016)
  • Author(s): Motoshi Komatsubara, Takayuki Hara, Tomohiro Terasaka, Takeshi Hosoya, Kishio Toma, Naoko Yamauchi, Kenichi Inagaki and Fumio Otsuka
  • Organizer: ENDO 2016
  • Place of Presentation: Boston (USA)
  • Year and Date: 2016-04-01
• [Presentation] MelatoninとBMP-4・副腎皮質ステロイドによるカテコラミン合成への影響 (2016)
  • Author(s): 小松原 基志、稲垣兼一、寺坂 友博、和田 淳、大塚 文男
  • Organizer: 日本ステロイドホルモン学会学術集会
  • Place of Presentation: 倉敷市芸文館（岡山県倉敷市）
  • Year and Date: 2016-01-15
• [Presentation] メラトニンとアクチビンによる副腎皮質アルドステロン合成への相互作用 (2015)
  • Author(s): 原孝行 稲垣兼一
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ東京
  • Year and Date: 2015-04-23 – 2015-04-25
• [Presentation] カテコラミン分泌に対するメラトニンの影響：PC12細胞を用いた検討 (2015)
  • Author(s): 小松原基志 稲垣兼一
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ東京
  • Year and Date: 2015-04-23 – 2015-04-25
• [Presentation] メラトニンによる副腎皮質アルドステロン分泌への影響と機序 (2014)
  • Author(s): 原孝行 稲垣兼一
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-04-24 – 2014-04-26