Analyzing the mechanism of TKI-resistance in Ph-positive ALL
Project/Area Number |
25461404
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Hokkaido University |
Principal Investigator |
KONDO TAKESHI 北海道大学, 医学(系)研究科(研究院), 講師 (70333606)
|
Co-Investigator(Kenkyū-buntansha) |
OHBA Yusuke 北海道大学, 大学院医学研究科, 教授 (30333503)
|
Co-Investigator(Renkei-kenkyūsha) |
MINAMI YOSUKE 神戸大学, 医学部附属病院, 講師 (60513752)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | BCR-ABL / TKI / Ph+ALL / チロシンキナーゼ阻害剤 / SUMO化 / leukemia / Leukemia / Drug Resistance |
Outline of Final Research Achievements |
Using the FRET-based drug sensitivity test, we identified and isolated TKI-rafractory cell population in Ph-positive ALL. Analysis of gene expression profile in TKI-refractory cells indicated that so many intracellular pathways were activated. One of them was sumoylation pathway. In vitro analysis, we proved that BCR-ABL is sumoylated. Moreover, inhibition of sumoylation effectively induced apoptosis in Ph+ALL cells.
|
Report
(4 results)
Research Products
(9 results)
-
[Journal Article] Pharmacokinetics and pharmacodynamics of dasatinib in the chronic phase of newly diagnosed chronic myeloid leukemia.2016
Author(s)
Ishida Y, Murai K, Yamaguchi K, Miyagishima T, Shindo M, Ogawa K, Nagashima T, Sato S, Watanabe R, Yamamoto S, Hirose T, Saitou S, Yonezumi M, Kondo T, Kato Y, Mochizuki N, Ohno K, Kishino S, Kubo K, Oyake T, Ito S; Inter-Michinoku Dasatinib Study Group (IMIDAS)
-
Journal Title
Eur J Clin Pharmacol.
Volume: 72
Issue: 2
Pages: 185-193
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Ultra-high level of serum soluble interleukin-2 receptor at diagnosis predicts poor outcome for angioimmunoblastic T-cell lymphoma.2015
Author(s)
Shiratori S, Kosugi-Kanaya M, Shigematsu A, Kobayashi H, Yamamoto S, Kobayashi N, Iwasaki H, Mori A, Kunieda Y, Yutaka T, Kurosawa M, Kakinoki Y, Endo T, Kondo T, Hashino S, Teshima T
-
Journal Title
Leukemia & Lymphoma
Volume: -
Issue: 9
Pages: 2592-2597
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
[Presentation] IDENTIFICATION OF FIP1L1-PDGFRA ASSOCIATING MOLECULE THAT LOCATES IN THE NUCLEUS AND AUGMENTS THE ACTIVITY OF FIPAL1-PDGFRA.2015
Author(s)
Takeshi Kondo, Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima
Organizer
European Association of Hematology 20th Congress
Place of Presentation
Vienna (Austria)
Year and Date
2015-06-11
Related Report
Int'l Joint Research
-
[Presentation] FRET-based drug sensitivity test predicts clinical response of nilotinib in CML-CP patients.2014
Author(s)
Kondo T, Ohba Y, Fujisawa S, Miyagishima T, Mori A, Iwasaki H, Shindo M, Kakinoki Y, Kobayashi N, Yamamoto S, Haseyama Y, Ando S, Kohgo Y, Teshima T
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場( 大阪府・大阪市 )
Year and Date
2014-10-31 – 2014-11-02
Related Report
-
[Presentation] MULTICENTER CLINICAL STUDY TO EVALUATE A UTILITY OF FRET-BASED DRUG SENRITIVITY TEST THAT PREDICTS EARLY MOLECULAR RESPONSE IN NEWLY DIAGNOSED CML PATIENTS TREATED WITH NILOTINIB2014
Author(s)
Kondo T, Ohba Y, Miyagishima T, Mori A, Iwasaki H, Shindo M, Kakinoki Y, Kobayashi N, Yamamoto S, Haseyama Y, Ando S, Fujimoto N, Nishio M, Kurosawa M, Kohgo Y, Teshima T
Organizer
European Association of Hematology 19th Congress
Place of Presentation
Milan ( Italy )
Year and Date
2014-06-12 – 2014-06-15
Related Report
-
[Presentation] Impact of Genetic Alterlations and MRD Reduction on the Outcome of Intermediate-Risk Acute Myelogenous Leukemia.2014
Author(s)
Kondo T, Fujisawa S, Sato A, Mori A, Imai K, Yamamoto S, Kakinoki Y, Miyagishima T, Tsutsumi Y, Haseyama Y, Wada Y, Kurosawa M, Iwasaki H, Imamura M, Teshima T
Organizer
5th JSH International Symposium
Place of Presentation
アクトシティ浜松コングレスセンター( 静岡県・浜松市 )
Year and Date
2014-05-24 – 2014-05-25
Related Report