Biological characteristics of the novel erythropoietin designed to bind to Heparin-like Substances

• Project/Area Number: 25461410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Niigata University
• Principal Investigator: MORIYAMA Masato 新潟大学, 医歯学系, 准教授 (30598131)
• Co-Investigator(Kenkyū-buntansha): OZAWA Takuya 新潟大学, 医歯学系, 助教 (70467075)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: エリスロポエチン / ヘパリン親和性 / サイトカイン / 造血活性 / 血管増殖阻害 / ヘパリン結合ドメイン / 組織保護 / 細胞外マトリックス

Outline of Final Research Achievements

Erythropoietin (EPO) has been used as an erythropoietic stimulant, and it also shows tissue-protective effects. We synthesized a hybrid molecule of EPO;heparin-binding EPO (HEPO), and studied the characteristics of this novel EPO derivative. Human HEPO (rhHEPO) shows not only long-acting erythropoietic activity, but also antiangiogenic effect. This novel EPO derivative (HEPO) may have an advantage to inhibit tumor growth while preserving hematopoietic and tissue-protective effects.

Research Products

• [Journal Article] Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation. (2016)
  • Author(s): Nomura S, Maeda Y, Ishii K, Katayama Y, Yagi H, Fujishima N, Ota S, Moriyama M, Ikezoe T, Miyazaki Y, Hayashi K, Fujita S, Satake A, Ito T, Kyo T, Tanimoto M.
  • Journal Title: J Blood Med. Volume: 7 Pages: 1-4
  • DOI: 10.2147/jbm.s93008
  • Peer Reviewed / Open Access
• [Journal Article] Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome. (2015)
  • Author(s): Moriyama M, Yano T, Furukawa T, Takada T, Ushiki T, Masuko M, Takizawa J, Sone H, Tazawa R, Saijo Y, Ishii H, Nakata K.
  • Journal Title: Ann Am Thorac Soc. Volume: 8 Pages: 1251-3
  • Peer Reviewed
• [Journal Article] 血栓形成の最初期段階における病態機序の解明とvon Willebrand因子（VWF）関連検査の有用性の検討 (2014)
  • Author(s): 森山雅人
  • Journal Title: 新潟県医師会報 Volume: 776 Pages: 8-10
  • Acknowledgement Compliant
• [Book] Erythropoietic Stimulating Agents (2013)
  • Author(s): Ken Toba and Masato Moriyama
  • Total Pages: 10
  • Publisher: Bentham Science