Establishment of novel treatment for patients with BCR-ABL-related diseases
| Project/Area Number |
25461417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
ORITANI KENJI 大阪大学, 医学(系)研究科(研究院), 准教授 (70324762)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA YUZURU 大阪大学, 大学院医学系研究科, 教授 (20177489)
ICHII MICHIKO 大阪大学, 大学院医学系研究科, 寄附講座助教 (30633010)
SAITOH NORIMITSU 大阪大学, 大学院医学系研究科, 助教 (30597399)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アダプター蛋白 / シグナル / 腫瘍化 / 炎症反応 / 免疫応答 / STAP / BCR-ABL / ケモカイン / 腫瘍 / 炎症 / アレルギー / STAP-2 / 内科 / 造血器疾患 / シグナル伝達 |
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| Outline of Final Research Achievements |
Signal transducing adaptor protein-2 (STAP-2) is an adaptor protein, which interacts with several signaling or transcriptional molecules. In this study, we found that STAP-2 enhances in vivo inflammatory (DSS-induced colitis) and immune responses (T-cell responses after the stimulation of T-cell receptor) as well as tumorigenesis of chronic myelogenous leukemia and melanoma. In BCR-ABL-mediated signals, STAP-2 expression changed the expression patterns of chemokine receptors, resulting in unique proliferation via interactions between CCR7 and its ligands (CCL19 or CCL21). Our results clearly indicate possible diseases for a novel STAP-2-targetting therapy.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Signal-Transducing Adaptor Protein-2 Controls the IgE-Mediated, Mast Cell-Mediated Anaphylactic Responses2014
Author(s)
Sekine Y, Nishida K, Yamasaki S, Muromoto R, Kon S, Kashiwakura JI, Saitoh K, Togi S, Yoshimura A, Oritani K, Matsuda T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Signal-Transducing Adaptor Protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate-induced colitis2014
Author(s)
Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saito K, Yoshimura A, Matsuda T, Kanakura Y
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Journal Title
Ｅｕｒ Ｊ Ｉｍｍｕｎｏｌ
Volume: 印刷中
Related Report
Peer Reviewed
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[Presentation] The role of Signal-Transducing Adaptor Protein-2 in early T lymphopoiesis in thymus2014
Author(s)
Ichii M, Fujita N, Maeda T, Okuzaki D, Sekine Y, Kon S, Muromoro R, Oritani K, Matsuda T, Kanakura Y
Organizer
The American Society of Hematology 56th Annual Meeting
Place of Presentation
San Francisco, CA, USA
Year and Date
2014-12-09
Related Report
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[Presentation] Regulation of B lymphopoiesis by Signal-Transducing Adaptor Protein-2, STAP-22014
Author(s)
Ichii M, Oritani K, Fujita N, Saitoh N, Sekine Y, Muromoto R, Kon S, Saitoh K, Matsuda T, Kanakura Y
Organizer
19th Congress of the European Hematology Association
Place of Presentation
Milan, Italy
Year and Date
2014-06-13
Related Report
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