| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
I have elucidated that transcription factorA and its co-factorB are required for almost all leukemogenesis.It is quite important findings to isolate one of the best targets for leukemia therapy.I have generated novel anti-leukemia drugs D which extend the life spans of mice models such as PhALL(T315I)and MLL-AF4+FLT3-ITD dramatically, suggesting the transcription facorA is novel pro-oncogenic factor for leukemogenesis.On the other hand, Solid tumores such as EGFR Inhibitor resistant NSCLC, Her2 positive gastric cancer, neuroblastoma were also down-regulated by drug D in xeno-grafted mice models.We have already isolated several small molecules(HITS) through Super-computional simulation(MD)
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