Identification and control of factors which regulate CML stem cells
Project/Area Number |
25461425
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Saga University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
Kubota Yasuhi 佐賀大学, 医学部, 講師 (60570413)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 白血病 / 幹細胞 / 低酸素 / シクロデキストリン / BMI-1 / HIF-1α / 慢性骨髄性白血病 |
Outline of Final Research Achievements |
We reported that higher expression of HIF-1alpha became a trigger of lymphoma. In addition, we reported that cyclodextrin and BIM-1 inhibitor showed higher efficacy against leukemic stem cells than normal hematopoietic stem cells and these compounds were promising candidates for novel agents for hematological malignancies. We made it clear that hypoxemia was closely related to hematological malignancies and novel agents which targeted for hypoxemia were very important.
|
Report
(4 results)
Research Products
(13 results)
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[Journal Article] 2-Hydroxypropyl-β-cyclodextrin Acts as a Novel Anticancer Agent.2015
Author(s)
Yokoo M, Kubota Y, Motoyama K, Higashi T, Taniyoshi M, Tokumaru H, Nishiyama R, Tabe Y, Mochinaga S, Sato A, Sueoka-Aragane N, Sueoka E, Arima H, Irie T, Kimura S.
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Journal Title
PLoS One
Volume: 10
Issue: 11
Pages: 1705-1713
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival.2013
Author(s)
Sueoka E, Sueoka-Aragane N, Sato A, Ide M, Nakamura H, Sotomaru Y, Taya C, Yonekawa H, Kitagawa T, Kubota Y, Kimura S, Nakachi K, Tanimoto K
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Journal Title
PLoS One
Volume: 8
Issue: 4
Pages: e57833-e57833
DOI
Related Report
Peer Reviewed
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