| Project/Area Number |
25461480
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
KAWAHITO YUTAKA 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50336731)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOHNO MASATAKA 京都府立医科大学, 医学研究科, 講師 (60405256)
ASHIHARA EISHI 京都薬科大学, 薬学部, 教授 (70275197)
YAMAMOTO AIHIRO 京都府立医科大学, 医学研究科, 助教 (60589878)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 関節リウマチ / 骨髄由来抑制細胞 / MSDCs / コラーゲン誘導関節炎 / MDSCs |
|---|
| Outline of Final Research Achievements |
In this study, MDSCs (Myeloid-derived suppressor cells) accumulated in the spleens of mice with CIA (collagen induce arthritis) when arthritis severity peaked. These MDSCs inhibited the proliferation of CD4+ T cells and their differentiation into Th17 cells in vitro. Moreover, MDSCs inhibited IFN-γ, IL-2, TNFα, and IL-6 by CD4+ T cells in vitro, which is antigen non-specific T cell response. Adoptive transfer of MDSCs reduced the severity of CIA in vivo. In conclusion, MDSCs in CIA suppress the progression of CIA by inhibiting the pro-inflammatory immune response of CD4+ T cells. These observations suggest that MDSCs play crucial roles in the regulation of autoimmune arthritis, which could be exploited in new cell-based therapies for human rheumatoid arthritis.
|
