| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Previous studies have shown that disulfide-linked homodimerization of FcRγ-chains is important for mast cell activation via the FcεRI complex. However, the biological significances of the disulfide-linked FcRγ dimerization in the FcεRI-mediated mast cell activation are largely unknown. In this study, we revealed for the first time that, in murine mast cell, FcRγ dimerization through the Cys7 residue is a crucial process for controlling degranulation and cytokine production, depending on the strength of FcεRI stimulation. In addition, we showed that the FcRγ dimerization enhances the stability of FcεRI complex in the presence of strong detergents. Our findings of the present study could deepen our understanding of mast cells activation process.
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