| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The aim of this study is to develop a new, simple, and highly sensitive method to detect minimal residual disease (MRD) in acute leukemia. Nano particles having sugar chain which can bind specifically WT1 protein released from leukemic cells were made. After condensing WT1 protein by nano particles, WT1 level was measured by ELISA. Nano MRD method is much simpler and cheaper compared to other methods detecting MRD including flowcytometory or PCR. Nano MRD method is about 50-times more sensitive than regular ELISA method. Nano MRD method should be useful to detect MRD in leukemia patient.
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