| Project/Area Number |
25461606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川原 勇太 自治医科大学, 医学部, 助教 (10570385)
塩田 曜子 国立研究開発法人国立成育医療研究センター, 小児がんセンター, 医師 (30307532)
早瀬 朋美 自治医科大学, 医学部, 助教 (50433587)
八木 正樹 自治医科大学, 医学部, 研究員 (60570398)
新島 瞳 (松本瞳 / 松本 瞳 / 新島 瞳(松本瞳)) 自治医科大学, 医学部, 助教 (70598937)
翁 由紀子 自治医科大学, 医学部, 助教 (30438650)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ランゲルハンス細胞組織球症 / ケモカイン / osteopontin / 破骨細胞様巨細胞 / 遺伝子多型 / サイトカイン / 多型性 |
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| Outline of Final Research Achievements |
The serum levels of IL-9, IL-10, IL-15 and MIF in patients with Langerhans cell histiocytosis (LCH) were significantly high compared to those in Control. The serum levels of M-CSF and CCL 2 in patients with multisystem (MS) type LCH were significantly high compared to those in patients with single-system (SS) type LCH, while the serum levels of IL-18 and osteopontin (OPN) in patients with risk organ involvement (RO) positive MS type LCH were significantly high compared to those in patients with RO negative MS type LCH.
OPN was revealed to be essential for differentiation from immature dendritic cells to osteoclast-like giant cells.
In 48 LCH patients, OPN gene polymorphisms (rs9138, rs4754, rs11730582, rs1126772, rs1126616) were analyzed. No significant difference was identified in allele frequencies of these sites between LCH patients and controls, patients diagnosed under 2-years-old and over 2-years-old, patients with MS type and SS type, patients with MS-RO (+)and MS-RO (-).
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