| Project/Area Number |
25461607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAGI Yasuyo 東京医科大学, 医学部, 准教授 (00287129)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 筋注 / 自然免疫 / 獲得免疫 / 炎症性サイトカイン / アジュバント / 炎症反応 / ヒトパピローマウイルスワクチン / 好中球 / ワクチン / 皮下接種 / 同時接種 / サイトカイン / 安全性 / 副反応 / 筋拘縮症 |
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| Outline of Final Research Achievements |
All current vaccines were investigated in mouse model. Inflammatory nodules spread into muscle bundle space without the degeneration and atrophic changes of muscle cells, which were observed in muscle contracture. Cytokine profiles were examined in muscle tissues after immunization. IL-1β, IL-6, TNF-α, 1L-4, and G-CSF levels increased 3 h after vaccination with Alum-adjuvanted vaccines at the injection sites, and decreased 7days and afterwards.
No significant difference in inflammatory cytokines was observed between the febrile and non-febrile groups, but higher than in normall suubjects. The mean G-CSF level was higher in the febrile group than in non-febrile group.
Inflammatory responses are shown to modulate adaptive immune responses and associate with local reactions as adverse reactions.
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