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The effects of hydrogen gas inhalation for hypoxic-ischemic encephalopathy in piglets.

Research Project

Project/Area Number 25461647
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa University

Principal Investigator

Kusaka Takashi  香川大学, 医学部, 教授 (50274288)

Co-Investigator(Kenkyū-buntansha) 安田 真之  香川大学, 医学部附属病院, 講師 (00380155)
久保井 徹  独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, 小児科, 医長 (00437683)
小久保 謙一  北里大学, 医療衛生学部, 准教授 (20287965)
小谷野 耕佑  香川大学, 医学部附属病院, 助教 (20437685)
岡田 仁  香川大学, 医学部, 准教授 (30253272)
三木 崇範  香川大学, 医学部, 教授 (30274294)
岩瀬 孝志  香川大学, 医学部附属病院, 講師 (30284368)
上野 正樹  香川大学, 医学部, 教授 (30322267)
中村 信嗣  香川大学, 医学部附属病院, 助教 (30437686)
岡崎 薫  独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, 小児科, その他 (40648614)
小林 弘祐  北里大学, 医療衛生学部, 教授 (70153632)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords新生児低酸素性虚血性脳症 / 水素ガス / 低体温療法 / 近赤外線分光法 / 脳血液量 / 脳内Hb酸素飽和度 / 新生仔豚 / 新生児仮死 / 水素 / 近赤外光 / 脳内Hb酸素飽和度 / エダラボン / 低酸素性虚血性脳症 / 新生児 / 動物モデル / 活性酸素 / 脳波
Outline of Final Research Achievements

The aim of this study is to evaluate the effectiveness of free radical scavenger (edaravone, EV) combined with hypothermia (HT) for hypoxic-ischemic (HI) brain injury, and the safety of hydrogen gas inhalation in neonatal piglets. The following results had been reported. At first, there was a positive linear correlation between changes in cerebral blood volume and low-amplitude aEEG duration during 12 h after the insult in the no-therapy group, but a negative linear correlation between these two parameters in the HT group. Secondly, both HT and HT+EV groups showed lower histopathological cerebral damages compared to that of no-therapy, especially in gray and white matter. However, HT+EV did not show lower damages compared to HT. Lastly, hydrogen gas inhalation had no effects on circulatory and metabolic activities, especially cerebral hemodynamics and oxygen metabolism, and cortical electrical activity. Therefore, hydrogen gas is likely to be used safely in neonatal medicine.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (47 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (24 results) (of which Peer Reviewed: 22 results,  Open Access: 16 results,  Acknowledgement Compliant: 4 results) Presentation (23 results)

  • [Journal Article] Prolonged maternal separation attenuates BDNF-ERK signaling correlated with spine formation in the hippocampus during early brain development.2017

    • Author(s)
      Ohta KI, Suzuki S, Warita K, Kaji T, Kusaka T, Miki T.
    • Journal Title

      J Neurochem.

      Volume: 141 Issue: 2 Pages: 179-194

    • DOI

      10.1111/jnc.13977

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.2017

    • Author(s)
      Kubo H, Shimono R, Nakamura S, Koyano K, Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
    • Journal Title

      Neonatology

      Volume: 111 Issue: 3 Pages: 203-210

    • DOI

      10.1159/000450721

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Burst Suppression in Hypothermia After Cardiac Arrest Because of Drowning Treated with Targeted Temperature Management: A Case Report.2016

    • Author(s)
      Okazaki T, Hifumi T, Egawa S, Hamaya H, Shinohara N, Kawamoto S, Iwaki T, Tsukahara K, Kawakita K, Kusaka T, Kuroda Y.
    • Journal Title

      Ther Hypothermia Temp Manag

      Volume: - Issue: 2 Pages: 107-110

    • DOI

      10.1089/ther.2016.0036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of bilirubin displacement effect by acetaminophen in vitro.2015

    • Author(s)
      Sugino M, Okada H, Kusaka T, Itoh S.
    • Journal Title

      Ann Clin Biochem

      Volume: 52 Issue: 4 Pages: 476-480

    • DOI

      10.1177/0004563214567477

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets.2015

    • Author(s)
      Nakamura M, Jinnai W, Hamano S, Nakamura S, Koyano K, Chiba Y, Kanenishi K, Yasuda S, Ueno M, Miki T, Hata T, Kusaka T.
    • Journal Title

      International Journal of Developmental Neuroscience

      Volume: 42 Issue: 1 Pages: 1-9

    • DOI

      10.1016/j.ijdevneu.2015.02.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of cerebral circulation and oxygen metabolism in infants using near-infrared light.2014

    • Author(s)
      Kusaka T, Isobe K, Yasuda S, Koyano K, Nakamura S, Nakamura M, Ueno M, Miki T, Itoh S.
    • Journal Title

      Brain Dev.

      Volume: 36 Issue: 4 Pages: 277-283

    • DOI

      10.1016/j.braindev.2013.05.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between early changes in cerebral blood volume and electrocortical activity after hypoxic-ischemic insult in newborn piglets.2014

    • Author(s)
      Nakamura S, Kusaka T, Koyano K, Miki T, Ueno M, Jinnai W, Yasuda S, Nakamura M, Okada H, Isobe K, Itoh S.
    • Journal Title

      Brain Dev

      Volume: 36 Issue: 7 Pages: 563-571

    • DOI

      10.1016/j.braindev.2013.08.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinically mild encephalitis/encephalopathy with a reversible splenial lesion caused by human parvovirus b19 infection: a case of two brothers with hereditary spherocytosis.2014

    • Author(s)
      Suzuki H, Kusaka T, Okada H.
    • Journal Title

      Pediatr Neurol

      Volume: 51 Issue: 3 Pages: 470-472

    • DOI

      10.1016/j.pediatrneurol.2014.05.021

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in (99m)Tc-ECD SPECT and magnetic resonance angiography with sporadic hemiplegic migraine in a child.2014

    • Author(s)
      Koyano K, Konishi Y, Okada H, Kusaka T, Itoh S.
    • Journal Title

      Clin Nucl Med

      Volume: 39 Issue: 5 Pages: 483-484

    • DOI

      10.1097/rlu.0000000000000401

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoreactivity of glucose transporter 5 is located in epithelial cells of the choroid plexus and ependymal cells.2014

    • Author(s)
      Ueno M, Nishi N, Nakagawa T, Chiba Y, Tsukamoto I, Kusaka T, Miki T, Sakamoto H, Yamaguchi F, Tokuda M.
    • Journal Title

      Neuroscience

      Volume: 260 Pages: 149-157

    • DOI

      10.1016/j.neuroscience.2013.12.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolonged maternal separation disturbs the serotonergic system during early brain development2014

    • Author(s)
      Ohta KI, Miki T, Warita K, Suzuki S, Kusaka T, Yakura T, Liu JQ, Tamai M, Takeuchi Y
    • Journal Title

      Int J Dev Neurosci

      Volume: 33 Issue: 1 Pages: 15-21

    • DOI

      10.1016/j.ijdevneu.2013.10.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early postnatal repeated maternal deprivation causes a transient increase in OMgp and BDNF in rat cerebellum suggesting precocious myelination2014

    • Author(s)
      Miki T, Yokoyama T, Kusaka T, Suzuki S, Ohta K, Warita K, Wang ZY, Sumitani K, Bellinger FP, Tamai M, Liu JQ, Yakura T, Takeuchi Y
    • Journal Title

      J Neurol Sci, J Neurol Sci

      Volume: 336 Issue: 1-2 Pages: 62-7

    • DOI

      10.1016/j.jns.2013.10.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.2014

    • Author(s)
      Miki T, Kusaka T, Yokoyama T, Ohta K, Suzuki S, Warita K, Jamal M, Wang ZY, Ueki M, Liu JQ, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y.
    • Journal Title

      J Neural Transm.

      Volume: 121 Issue: 2 Pages: 201-210

    • DOI

      10.1007/s00702-013-1085-y

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 新生児低酸素性虚血性脳症2014

    • Author(s)
      日下隆
    • Journal Title

      日本小児科学会雑誌

      Volume: 118 Pages: 1565-1577

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] 近赤外光分析法2014

    • Author(s)
      日下隆
    • Journal Title

      周産期医学

      Volume: 44 Pages: 797-802

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of cerebral circulation and oxygen metabolism in infants using near-infrared light.2014

    • Author(s)
      Kusaka T, Isobe K, Yasuda S, Koyano K, Nakamura S, Nakamura M, Ueno M, Miki T, Itoh S.
    • Journal Title

      Brain Dev.

      Volume: 36 Pages: 277-283

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early postnatal repeated maternal deprivation causes a transient increase in OMpg and BDNF in rat cerebellum suggesting precocious myelination.2014

    • Author(s)
      Miki T, Yokoyama T, Kusaka T, Suzuki S, Ohta K, Warita K, Wang ZY, Ueki M, Sumitani K, Bellinger FP, Tamai M, Liu JQ, Yakura T, Takeuchi Y.
    • Journal Title

      J Neurol Sci.

      Volume: 336 Pages: 62-67

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.2014

    • Author(s)
      Miki T, Kusaka T, Yokoyama T, Ohta K, Suzuki S, Warita K, Jamal M, Wang ZY, Ueki M, Liu JQ, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y.
    • Journal Title

      J Neural Transm.

      Volume: 121 Pages: 201-210

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between early changes in cerebral blood volume and electrocortical activity after hypoxic-ischemic insult in newborn piglets.2013

    • Author(s)
      Nakamura S, Kusaka T, Koyano K, Miki T, Ueno M, Jinnai W, Yasuda S, Nakamura M, Okada H, Isobe K, Itoh S.
    • Journal Title

      Brain Dev.

      Volume: Epub ahead of print

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cerebral blood volume combined with amplitude-integrated EEG can be a suitable guide to control hypoxic/ischemic insult in a piglet model.2013

    • Author(s)
      Nakamura S, Kusaka T, Yasuda S, Ueno M, Miki T, Koyano K, Nakamura M, Okada H, Okazaki K, Isobe K, Itoh S.
    • Journal Title

      Brain Dev.

      Volume: 35 Pages: 614-625

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of blood transfusion on cerebral hemodynamics in preterm infants.2013

    • Author(s)
      Koyano K, Kusaka T, Nakamura S, Nakamura M, Konishi Y, Miki T, Ueno M, Yasuda S, Okada H, Nishida T, Isobe K, Itoh S.
    • Journal Title

      Transfusion

      Volume: 53 Pages: 1459-1467

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 低酸素性虚血性脳症における脳循環・代謝の病態生理とこれからの治療戦略2013

    • Author(s)
      日下隆、安田真之、小谷野耕佑、中村信嗣、中村信、神内済、三木崇範、上野正樹、磯部健一、伊藤進
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 49 Pages: 1172-1175

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early postnatal maternal separation causes alterations in the expression of β3-adrenergic receptor in rat adipose tissue suggesting long-term influence on obesity.2013

    • Author(s)
      Miki T, Liu JQ, Ohta K, Suzuki S, Kusaka T, Warita K, Yokoyama T, Jamal M, Ueki M, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 442 Pages: 68-71

    • Related Report
      2013 Research-status Report
  • [Journal Article] Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by near-infrared time-resolved spectroscopy

    • Author(s)
      Nakamura S, Koyano K, Jinnai W, Hamano S, Yasuda S, Konishi Y, Kuboi T, Kanenishi K, Nishida T, Kusaka T
    • Journal Title

      Brain & Dev

      Volume: 37 Issue: 10 Pages: 925-932

    • DOI

      10.1016/j.braindev.2015.04.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 新生児のビリルビンと酸素代謝の特異性2017

    • Author(s)
      日下隆
    • Organizer
      第7回新生児科指導医教育セミナー
    • Place of Presentation
      宮城県仙台市 TKPガーデンシティ仙台
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新生児期におけるビリルビンと酸素代謝の特異性2016

    • Author(s)
      日下隆
    • Organizer
      第89回日本小児科学会高知地方会
    • Place of Presentation
      高知
    • Year and Date
      2016-02-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 近赤外光を利用した新生児の脳機能評価2015

    • Author(s)
      日下隆
    • Organizer
      第3回新胎児学研究会
    • Place of Presentation
      高松
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 新生児低酸素性虚血性脳症における脳循環・代謝2015

    • Author(s)
      日下隆
    • Organizer
      第67回中国四国小児科学会
    • Place of Presentation
      山口
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 新生児における脳循環・酸素代謝の評価2015

    • Author(s)
      日下隆
    • Organizer
      長野県周産期カンファランス
    • Place of Presentation
      長野
    • Year and Date
      2015-10-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 光を用いた新生児の脳循環と機能評価2015

    • Author(s)
      日下隆
    • Organizer
      第33回周産期学シンポジウム
    • Place of Presentation
      静岡県浜松市 アクトシティ浜松
    • Year and Date
      2015-01-23 – 2015-01-24
    • Related Report
      2014 Research-status Report
  • [Presentation] これからの日本新生児医療の未来への提言2014

    • Author(s)
      日下隆
    • Organizer
      新生児医療連絡会30周年記念講演会
    • Place of Presentation
      愛媛県松山市 ひめぎんホール
    • Year and Date
      2014-11-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 低酸素性虚血性脳症における脳循環と酸素代謝2014

    • Author(s)
      日下隆
    • Organizer
      第59回日本未熟児新生児学会・学術集会
    • Place of Presentation
      愛媛県松山市 ひめぎんホール
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 脳循環指標を用いた早産児貧血における輸血療法基準作成の検討2014

    • Author(s)
      小谷野耕佑、有岡誠、喜多條真穂、新居広一郎、若林誉幸、近藤健夫、神内済、中村信嗣、安田真之、日下隆
    • Organizer
      第59回日本未熟児新生児学会・学術集会
    • Place of Presentation
      愛媛県松山市 ひめぎんホール
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 新生仔豚を用いた低酸素虚血負荷後超早期における脳循環変化と病理学的脳障害の関係2014

    • Author(s)
      濱野聡史、中村信、神内済、中村信嗣、小谷野耕佑、安田真之、岩瀬孝志、岡田仁、日下隆
    • Organizer
      第50日本周産期・新生児医学会学術集会
    • Place of Presentation
      千葉県浦安市 シュラトン・グランデ・トーキョーベイ・ホテル
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 中枢血管拍動周期の早熟性は早産児の発達障害の要因か?2013

    • Author(s)
      日下隆、加藤育子、小西行彦、西田智子、磯部健一、伊藤進
    • Organizer
      第116回日本小児科学会
    • Place of Presentation
      広島県・広島市・広島国際会議場他
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生仔豚低酸素性虚血モデルでの蘇生後早期の脳循環変化と予後との関係2013

    • Author(s)
      日下隆、中村信嗣、小谷野耕佑、神内済、中村信、安田真之、伊藤進
    • Organizer
      第116回日本小児科学会
    • Place of Presentation
      広島県・広島市・広島国際会議場他
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生仔豚仮死モデルを用いた低酸素性虚血性脳症における脳循環と脳代謝の検討2013

    • Author(s)
      安田真之、鈴木裕美、浜野聡史、若林誉幸、神内済、小谷野耕佑、中村信嗣、中村信、日下隆、伊藤進
    • Organizer
      第116回日本小児科学会
    • Place of Presentation
      広島県・広島市・広島国際会議場他
    • Related Report
      2013 Research-status Report
  • [Presentation] Relationship between early changes in cerebral blood volume and electrocortical activity after hypoxic-ischemic insult in newborn piglets2013

    • Author(s)
      Nakamura Shinji, Kusaka Takashi, Koyano Kosuke, Miki Takanori, Uno Masaki, Jinnai Wataru, Yasuda Saneyuki, Nakamura Makoto, Okada Hitoshi, Isobe Kenichi, Itoh Susumu.
    • Organizer
      ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
    • Place of Presentation
      Borneo Convention Centre Kuching, Sarawak, Malaysia
    • Related Report
      2013 Research-status Report
  • [Presentation] Relationship between cerebral blood volume and cortical erectrical activity during hypothermia in piglet asphyxia model2013

    • Author(s)
      Jinnai Wataru, Kusaka Takashi, Wakabayashi Takayuki, Sugino Masashiro, Kunikata Jun, Nakamura Shinji, Koyano Kosuke, Ueno Masaki, Miki Takanori, Nakamura Makoto, Yasuda Saneyuki, Isobe Kenichi, Itoh Susumu.
    • Organizer
      ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
    • Place of Presentation
      Borneo Convention Centre Kuching, Sarawak, Malaysia
    • Related Report
      2013 Research-status Report
  • [Presentation] Influence of a free radical scavenger on neuronal damage in a newborn piglet hypoxic-ischemic model.2013

    • Author(s)
      Kusaka Takashi, Nakamura Shinji, Koyano Kosuke, Jinnai Wataru, Nakamura Makoto, Yasuda Saneyuki, Ueno Masaki, Miki Takanori, Itoh Susumu.
    • Organizer
      ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
    • Place of Presentation
      Borneo Convention Centre Kuching, Sarawak, Malaysia
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation between pathological and aEEG scoring after hypoxic-ischemic insult in newborn piglet model.2013

    • Author(s)
      Nakamura M, Nakamura S, Koyano K, Jinnai W, Kunikata J, Yasuda S, Miki T, Ueno M, Kusaka T, Isobe K, Itoh S.
    • Organizer
      ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
    • Place of Presentation
      Borneo Convention Centre Kuching, Sarawak, Malaysia
    • Related Report
      2013 Research-status Report
  • [Presentation] Relationship between interoptode distance and optical pathlength factor in infants assessed by near-infrared diffuse optical tomography.2013

    • Author(s)
      Kusaka Takashi, Nakamura Shinji, Koyano Kosuke, Yasuda Saneyuki, Okawa Shinpei, Tanikawa Yukari, Feng Gao, Sato Chie, Hoshi Yoko, Yamada Yukio, Itoh Susumu.
    • Organizer
      ASPR-PSM 2013 Joint scientific Meeting 9th ASPR Congress & 20th PSM Annual Congress
    • Place of Presentation
      Borneo Convention Centre Kuching, Sarawak, Malaysia
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生仔豚を用いた低酸素性虚血性脳症モデルにおけるエダラボンの効果:病理組織学的検討2013

    • Author(s)
      小谷野耕佑、新居広一郎、冨田理絵、神内済、中村信嗣、安田真之、日下隆、伊藤進
    • Organizer
      第40回日本小児臨床薬理学会学術集会
    • Place of Presentation
      神奈川県・横浜市・慶應義塾大学日吉キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生児における脳低温療法施行・非施行低酸素性虚血性脳症例の脳循環代謝変化 生後72時間までの脳血液量、脳内Hb酸素飽和度2013

    • Author(s)
      浜野 聡史, 神内 済, 國方 淳, 小谷野 耕佑, 安田 真之, 岩瀬 孝志, 日下 隆, 伊藤 進
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      石川県・金沢市・石川県立音楽堂他
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生仔豚仮死モデルを用いた遅発性脳エネルギー代謝障害時の脳循環と脳代謝の基礎的検討(第4報)2013

    • Author(s)
      安田 真之, 神内 済, 中村 信嗣, 小谷野 耕佑, 中村 信, 日下 隆, 伊藤 進
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      石川県・金沢市・石川県立音楽堂他
    • Related Report
      2013 Research-status Report
  • [Presentation] 新生仔豚低酸素性虚血性脳症モデルにおける低酸素虚血負荷中の脳血液量の変化パターンと病理組織との関係2013

    • Author(s)
      神内 済, 中村 信嗣, 濵野 聡史, 若林 誉幸, 國方 淳, 小谷野 耕佑, 安田 真之, 中村 信, 日下 隆, 伊藤 進
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      石川県・金沢市・石川県立音楽堂他
    • Related Report
      2013 Research-status Report
  • [Presentation] 左中大脳動脈領域の脳梗塞症例における脳循環代謝変化の経時的変化について2013

    • Author(s)
      中村 信嗣, 神内 済, 國方 淳, 小谷野 耕佑, 安田 真之, 岩瀬 孝志, 日下 隆, 伊藤 進
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      石川県・金沢市・石川県立音楽堂他
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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