| Project/Area Number |
25461665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Yokozeki Hiroo 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90210608)
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| Co-Investigator(Kenkyū-buntansha) |
IGAWA Ken 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00372441)
宇賀神 つかさ 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40581327)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 好塩基球 / 痒疹 / TH2サイトカイン / M2マクロファージ / STAT6 / IgE / プロテアーゼ / 蕁麻疹 / ＴＨ２サイトカイン / ＩｇＥ |
|---|
| Outline of Final Research Achievements |
Prurigo nodularis, prurigo type atopic dermatitis is a chronic and untreated diseases. In order to investigate a mechanism for prurigo reaction, we have been established a mouse model for prurigo by using a TNP-IgE transgenic mice (Immunity, 2005, Mukai K, J Immunol,2015, Hasimoto T et al). And we clarify that MT play a major role in the induction of IL-4 in basophils.
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