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The role of IRF5 in cutaneous inflammation and malignant melanoma

Research Project

Project/Area Number 25461685
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionSt. Marianna University School of Medicine (2015)
The University of Tokyo (2013-2014)

Principal Investigator

Kadono Takafumi  聖マリアンナ医科大学, 医学部, 准教授 (80292910)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsIRF5 / 接触皮膚炎 / 悪性黒色腫 / DNFB / FITC
Outline of Final Research Achievements

IRF5 is critical for immunity and induce the production of various inflammatory cytokines to regulate Th1-Th2 balance. In this study, we investigated the role of IRF5 for cutaneous inflammation using contact hypersensitivity model. In IRE5 deficient mice, Th1-type immune responses were significantly reduced, whereas Th2-type immune responses were significantly augmented due to the abnormality in sensitization phase. Dendritic cells are critical for sensitization and inducing immune responses. IRF5-deficient dendritic cells express less IL-12, which presumably leads to reduced Th1-type immune responses. In addition,the number of dendritic cells known to induce Th2-type immune responses were significantly augmented, which might cause increased Th2-type contact hypersensitivity. Thus, IRF5 is critical for balancing Th1-Th2 immune responses.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2014 2013

All Presentation (2 results)

  • [Presentation] IRF5はTh1型接触皮膚炎を誘導しTh2型接触皮膚炎を抑制する2014

    • Author(s)
      市村洋平, 門野岳史, 遠山哲夫, 山田大資, 増井友里, 佐藤伸一
    • Organizer
      第42回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 転写因子IRF5が接触皮膚炎に与える影響について2013

    • Author(s)
      市村洋平 門野岳史 遠山哲夫 山田大資 増井友里 佐藤伸一
    • Organizer
      第41回日本臨床免疫学会総会
    • Place of Presentation
      下関
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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