Genomic instabilities and tumorigenesis in epidermal keratinocytes

• Project/Area Number: 25461696
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokushima
• Principal Investigator: KUBO Yoshiaki 徳島大学, 大学院医歯薬学研究部, 教授 (10260069)
• Co-Investigator(Kenkyū-buntansha): ISHIGAMI Takeshi 徳島大学, 大学院医歯薬学研究部, 助教 (40464359) ; MATSUDATE Yoshihiro 徳島大学, 大学院医歯薬学研究部, 助教 (80622729)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 表皮細胞 / 腫瘍化 / 日光角化症 / Bowen病 / 有棘細胞癌 / セネッセンス / DNA損傷

Outline of Final Research Achievements

We examined the expression of senescence-related protein, macroH2A1, in actinic keratosis (AK), Bowen’s disease (BD), and squamous cell carcinoma (SCC) by immunohistochemical analysis. Immunoreactivity for macroH2A1 was greater in AK than in BD and SCC. We suppose that AK may progress to SCC by escaping from the state of senescence and the pathogenesis of BD may be different from that of AK.