Reclassification of schizophrenia by candidate gene and symptom
| Project/Area Number |
25461731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 統合失調症 / 亜型分類 / 臨床転帰 / 社会転帰 / 遺伝子解析 / PDE4B / リスクアレル / Polygenic risk score / 就労率 / 重症度 / 遺伝子研究 / 臨床経過 / CSMD-1 / ポリジェニックスコアー / SLC6A5 |
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| Outline of Final Research Achievements |
We investigated the association between genetics and clinical or social outcomes of about 500 patients with schizophrenia at the critical period. Among 7 SNPs of 6 genes (SLC6A5, DTNBP1, GRM7, PPP3CC, EGR3, and PDE4B) which participated in NMDA receptor function, rs894747 of SLC6A5 gene was related to severity of illness and social outcome. Rs472952 of PDE4B gene was related to low score of letter fluency test. In 91SNPs of GWAS analysis of Japanese patients with schizophrenia, each 3SNPs including rs2623659 of CSMD1 was related to severity of illness or social outcome. 3SNPs ralated with severity of illness was also related to treatment resistance. It is interesting that the genetic factor also influenced to the clinical or social outcomes of the patients with schizophrenia.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population2016
Author(s)
Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K, Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M et al
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Journal Title
Biol Psychiatry
Volume: in press
Issue: 8
Pages: 636-642
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes.2016
Author(s)
Sakamoto S, Takaki M, Okahisa Y, Mizuki Y, Inagaki M, Ujike H, Mitsuhashi T, Takao S, Ikeda M, Uchitomi Y, Iwata N, Yamada N.
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Journal Title
J Hum Genet.
Volume: 61
Issue: 4
Pages: 329-334
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Association Study of Dopamine β-Hydroxylase Gene with Methamphetamine Psychosis.2014
Author(s)
Okahisa Y, Ujike H, Takaki M, Mizuki Y, Sakamoto S, Mujun W, Kondo N, Naruse N, Aoyama-Uehara K, Iwata N, Iyo M,2, Sora I, Ozaki N, Uchitomi Y.
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Journal Title
Journal of Drug and Alcohol Research
Volume: 3
Pages: 1-6
Related Report
Peer Reviewed
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[Journal Article] Association Study of FYN Gene Polymorphism and Methamphetamine Use Disorder.2013
Author(s)
Sakamoto S, Okahisa Y, Takaki M, Mizuki Y, Kodama M, Aoyama-Uehara K, Won M, Kondo N, Naruse N, Sora I, Iwata N, Iyo M, Ozaki N, Ujike H, Uchitomi Y.
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Journal Title
Journal of Drug and Alcohol Research
Volume: 2
Related Report
Peer Reviewed
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[Presentation] Association study between EAAT2 gene polymorphism and Methamphetamine Psychosis2013
Author(s)
Shinji Sakamoto, Yuko Okahisa, Hiroshi Ujike, Yutaka Mizuki, Manabu Takaki, Masafumi Kodama, Kumi Aoyama, Won Mujun, Naoki Kondo, Nobuya Naruse, Ichiro Sora, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Yosuke Uchitomi
Organizer
WFSBP Congress 2013 11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto, Japan
Related Report
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[Presentation] Association between the Fyn kinase gene and patients with methamphetamine dependence2013
Author(s)
Sakamoto S, Okahisa Y, Takaki M, Mizuki Y, Kodama M, Aoyama-Uehara K, Won M, Kondo N, Naruse N, Sora I, Iwata N, Iyo M, Ozaki N, Ujike H, Uchitomi Y
Organizer
4th International Drug Abuse Research Society
Place of Presentation
Mexico City, Mexico
Related Report
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[Presentation] Association study of dopamine β-hydroxylase gene with methamphetamine dependence2013
Author(s)
Okahisa Y, Ujike H, Sakamoto S, Mizuki Y, Takaki M, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Iwata N, Iyo M, Sora I, Ozaki N, Uchitomi Y
Organizer
4th International Drug Abuse Research Society
Place of Presentation
Mexico City, Mexico
Related Report
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