The integrated study of both the neural basis and clinical assessment underlying longitudinal changes of neuropsychiatric symptoms in Alzheimer disease

• Project/Area Number: 25461782
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Keio University
• Principal Investigator: Nakaaki Shutaro 慶應義塾大学, 医学部, 准教授 (80315879)
• Co-Investigator(Kenkyū-buntansha): Mimura Masaru 慶応義塾大学, 医学部, 教授 (00190728) ; Torii Katsuyoshi 名古屋市立大学, 医学研究科, 研究員 (20551287) ; Miyata Jun 京都大学, 医学研究科, 講師 (90549099)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 認知症 / 精神症状 / テンソル画像 / FA値 / 縦断的変化 / 脳画像 / MRI / 脳形態画像 / 拡散テンソル画像

Outline of Final Research Achievements

The neural substrate underlying the longitudinal changes of neuropsychiatric symptoms in Alzheimer’s disease (AD) demetnia is unclear. In AD, we examined the longitudinal changes of white matter (WM) integrity using a diffusion tensor imaging (DTI) during a 2-year period in AD patients who did or who did not develop delusions. Compared with the baseline, both groups in AD have shown that the fractional antisotropy (FA) values have significantly reduced in both splenium of the corpus callosum, and bilateral temporal lobes after two years. On contrast, the FA values in the genu of the corpus callosum, bilateral frontal lobes have significantly reduced in only one group with the AD patients who developed delusions during a 2-year period. Abnormalities in WM integrity involving several fibers associated with the frontal lobe may be crucial to the longitudinal changes of delusions in AD patients.

Research Products

• [Journal Article] Predicting the neural effect of switching from donepezil to galantamine based on single-photon emission computed tomography findings in patients with Alzheimer's (2016)
  • Author(s): Oka Mizuki, Nakaaki Shutaro, Negi Atsushi, Miyata Jun, Nakagawa Atsuo, Hirono Nobutsugu, Mimura Masaru
  • Journal Title: Psychogeriatrics Volume: 16 Issue: 2 Pages: 121-134
  • DOI: 10.1111/psyg.12132
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Greater than the sum of its parts: δ improves upon a battery’s diagnostic performance (2015)
  • Author(s): Royall DR, Matsuoka T, Palmer RF, Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Nakaaki S, Koumi H, Mimura M, Fukui K, Narumoto J.
  • Journal Title: Neuropsychology Volume: 29 Issue: 5 Pages: 683-692
  • DOI: 10.1037/neu0000153
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease (2014)
  • Author(s): Banno K, Nakaaki S, Sato J, Torii K, Oka M, Negi A, Narumoto J, Miyata J, Hirono N, Furukawa TA, Mimura M & Akechi T
  • Journal Title: Neuropsychiatric Disease and Treatment. Volume: Feb 17;10 Pages: 339-348
  • DOI: 10.2147/ndt.s57522
  • Peer Reviewed / Open Access
• [Journal Article] Japanese versions of the executive interview (J-EXIT25) and the executive clock drawing task (J-CLOX) for older people (2014)
  • Author(s): Matsuoka T, Kato Y, Taniguchi S, Ogawa M, Fujimoto H, Okamura A, Shibata K, Nakamura K, Uchida H, Nakaaki
  • Journal Title: Int Psychogeriatr Volume: 26 Issue: 8 Pages: 1387-1397
  • DOI: 10.1017/s104161021400088x
  • Peer Reviewed
• [Journal Article] Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease. (2014)
  • Author(s): Banno K, Nakaaki S, Sato J, Torii K, Oka M, Negi A, Narumoto J, Miyata J, Hirono N, Furukawa TA, Mimura M & Akechi T
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Neuroanatomical abnormalities before onset of delusions in patients with Alzheimer's disease: a voxel-based morphometry study. (2013)
  • Author(s): Nakaaki S, Sato J, Torii K, Oka M, Negi A, Nakamae T, Narumoto J, Miyata J,
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 9 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Decreased white matter integrity before the onset of delusions in patients with Alzheimer's disease: diffusion tensor imaging. (2013)
  • Author(s): Nakaaki S, Sato J, Torii K, Oka M, Negi A, Nakamae T, Narumoto J, Miyata J,
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 9 Pages: 25-29
  • Peer Reviewed
• [Presentation] アルツハイマー病における生活習慣病、白質病変と精神症状との関連 (2015)
  • Author(s): 仲秋秀太郎，川口彰子, 佐藤順子，阪野公一, 根木淳, 田里久美子, 岡瑞紀，色本凉,
  • Organizer: 第30回日本老年精神医学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-13
• [Presentation] アルツハイマー病における妄想の縦断的変化の神経基盤 (2015)
  • Author(s): 根木淳,仲秋秀太郎，川口彰子, 佐藤順子，阪野公一, 田里久美子, 岡瑞紀，色本凉,
  • Organizer: 第30回日本老年精神医学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-13
• [Presentation] To explore the neural effects of cholinesterase inhibitors on the frontal lobe function in AD patients (2014)
  • Author(s): Mimura M, Oka M, Nakaaki S
  • Organizer: 14th ICGP & 19th JSNP Joint Congress
  • Place of Presentation: Tukuba, Japan
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] 認知症の前駆症状・初期症状 シンポジウム「アルツハイマー病の初期症状」 (2014)
  • Author(s): 仲秋秀太郎
  • Organizer: 第29回日本老年精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12
  • Invited
• [Presentation] The study of the relationship between white matter hyperintensities and neuropsychiatric symptoms in Alzheimer’s disease (2013)
  • Author(s): Shutaro Nakaaki
  • Organizer: The international congress on vascular dementia
  • Place of Presentation: Athens （Greece）
• [Presentation] 高齢者の生活と人生をささえる認知・行動評価 (2013)
  • Author(s): 仲秋秀太郎
  • Organizer: 日本精神保健・予防学会
  • Place of Presentation: 学術総合センター (東京)
  • Invited
• [Book] 医療従事者のための同意能力評価の進め方・考え方 (2015)
  • Author(s): 仲秋秀太郎
  • Publisher: 新興医学出版
• [Book] 精神疾患の脳画像ケースカンファレンス診断と治療へのアプローチ (2014)
  • Author(s): 仲秋秀太郎、川口彰子、橋本伸彦
  • Publisher: 中山書店
• [Book] 認知症ハンドブック (2013)
  • Author(s): 仲秋秀太郎, 佐藤順子
  • Publisher: 医学書院