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NIRS findings in Asperger disorder and ADHD

Research Project

Project/Area Number 25461784
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionShowa University

Principal Investigator

Iwanami Akira  昭和大学, 医学部, 教授 (80276518)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsADHD / ASD / NIRS / アスペルガー症候群 / 鑑別診断 / 発達障害
Outline of Final Research Achievements

In persons with AS, during the letter fluency task the change of Oxy-hemoglobin values was significantly smaller than that in controls. Also, in persons with ADHD, during the letter fluency task, the change of Oxy-hemoglobin values was significantly smaller than that in controls. We found that time-course patterns of [oxy-Hb] changes varied according to diagnosis and brain location. The group differences were seen during almost the whole task period at several clusters located in the left DLPFC and ventrolateral prefrontal cortex (VLPFC), and superior temporal gyrus.
We evaluated spontaneous Theory of Mind (ToM) ability in adults with ADHD and ASD without intellectual deficiency using an eye tracking task similar to a study of Senju et al. (2009).The results showed that there was not a significant difference in the ToM ability between ADHD and controls, although the ToM ability was impaired in persons with ASD.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2017 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results) Book (3 results)

  • [Journal Article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder2015

    • Author(s)
      Itahashi T, Yamada T, Watanabe H, Nakamura M, Ohta H, Kanai C, Iwanami A, Kato N, Hashimoto R.
    • Journal Title

      Mol Autism

      Volume: 6:30 Issue: 1 Pages: 1-14

    • DOI

      10.1186/s13229-015-0026-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A longitudinal functional neuroimaging study in medication-naive depression after antidepressant treatment.2015

    • Author(s)
      Tomioka H, Yamagata B, Kawasaki S, Pu S, Iwanami A, Hirano J, Nakagome K, Mimura M.
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 3 Pages: e0120828-e0120828

    • DOI

      10.1371/journal.pone.0120828

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] P300 component of event-related potentials in persons with asperger disorder2014

    • Author(s)
      Iwanami A1, Okajima Y, Ota H, Tani M, Yamada T, Yamagata B, Hashimoto R, Kanai C, Takashio O, Inamoto A, Ono T, Takayama Y, Kato N
    • Journal Title

      J Clin Neurophysiol

      Volume: 31 Issue: 5 Pages: 493-499

    • DOI

      10.1097/wnp.0000000000000080

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 発達障害と境界例2014

    • Author(s)
      岩波 明, 五十嵐 美紀, 森田 哲平
    • Journal Title

      精神科

      Volume: 25 Pages: 16-21

    • Related Report
      2014 Research-status Report
  • [Journal Article] アスペルガー障害における注意欠如・多動性障害の症状2014

    • Author(s)
      大野 泰正, 谷 将之, 山田 貴志, 橋本 龍一郎, 金井 智恵子, 高山 悠子, 岡島 由佳, 加藤 進昌, 岩波 明
    • Journal Title

      精神科

      Volume: 24 Pages: 717-722

    • Related Report
      2014 Research-status Report
  • [Journal Article] ADHDと注意機能2014

    • Author(s)
      岩波明
    • Journal Title

      精神科

      Volume: 24 Pages: 182-188

    • Related Report
      2013 Research-status Report
  • [Presentation] Reduced prefrontal activation in adult subjects with ADHD during a verbal fluency task2017

    • Author(s)
      Iwanami A, Okajima Y, Hayashi W
    • Organizer
      6th World Congress on ADHD
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical characteristics of adults with ADHD2017

    • Author(s)
      Hayashi W, Arai G, Iwanami A
    • Organizer
      6th World Congress on ADHD
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The ability of theory of mind in adults with ADHD2017

    • Author(s)
      Arai G, Saga N, Iwanami A
    • Organizer
      6th World Congress on ADHD
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessing attentional functios in adults with ADHD2017

    • Author(s)
      Saga N, Arai G, Iwanami A
    • Organizer
      6th World Congress on ADHD
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NIRS findings in adults with ADHD2015

    • Author(s)
      Okajima Yuka, Morita Teppei, Tokumasu Takahiro, Saga Nobuyuki, Yamagata Bun, Iwanami Akira
    • Organizer
      5th World Congress on ADHD
    • Place of Presentation
      グラスゴー
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical characteristics of adults with ADHD or ASD admitted to emergency psychiatric wards in Japan2015

    • Author(s)
      Morita Teppei, Yamada Hiroki, Tokumasu Takahiro, Saga Nobuyuki, Arai Goyu, Ikuse Daisuke, Iwanami Akira
    • Organizer
      5th World Congress on ADHD
    • Place of Presentation
      グラスゴー
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Similarity of subjective symptoms in persons with ADHD and Asperger’s disorder2015

    • Author(s)
      Tokumasu, Motira, Saga, Ikuse, Arai, Okajima, Iwanami
    • Organizer
      5th World Congress on ADHD
    • Place of Presentation
      グラスゴー
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comorbid symptoms in adults with ADHD2015

    • Author(s)
      Saga, Morita, Tokumasu, Arai, Ikuse, Okajima, Iwanami
    • Organizer
      5th World Congress on ADHD
    • Place of Presentation
      グラスゴー
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 成人ADHDにおける不安、抑うつ症状2014

    • Author(s)
      佐賀信之、森田哲平、徳増卓宏、五十嵐美紀、横井英樹、川久保由紀、岩波明
    • Organizer
      第34回日本精神科診断学会
    • Place of Presentation
      松山
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 成人期ADHDの臨床2014

    • Author(s)
      岩波明
    • Organizer
      第34回日本精神科診断学会
    • Place of Presentation
      松山
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 発達障害2017

    • Author(s)
      岩波明
    • Total Pages
      255
    • Publisher
      文藝春秋社
    • Related Report
      2016 Annual Research Report
  • [Book] 大人のADHD2015

    • Author(s)
      岩波明
    • Total Pages
      236
    • Publisher
      筑摩書房
    • Related Report
      2015 Research-status Report
  • [Book] 講談社2014

    • Author(s)
      岩波明
    • Total Pages
      190
    • Publisher
      発達障害を生きる
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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