NIRS findings in Asperger disorder and ADHD

• Project/Area Number: 25461784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Showa University
• Principal Investigator: Iwanami Akira 昭和大学, 医学部, 教授 (80276518)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ADHD / ASD / NIRS / アスペルガー症候群 / 鑑別診断 / 発達障害

Outline of Final Research Achievements

In persons with AS, during the letter fluency task the change of Oxy-hemoglobin values was significantly smaller than that in controls. Also, in persons with ADHD, during the letter fluency task, the change of Oxy-hemoglobin values was significantly smaller than that in controls. We found that time-course patterns of [oxy-Hb] changes varied according to diagnosis and brain location. The group differences were seen during almost the whole task period at several clusters located in the left DLPFC and ventrolateral prefrontal cortex (VLPFC), and superior temporal gyrus.
We evaluated spontaneous Theory of Mind (ToM) ability in adults with ADHD and ASD without intellectual deficiency using an eye tracking task similar to a study of Senju et al. (2009).The results showed that there was not a significant difference in the ToM ability between ADHD and controls, although the ToM ability was impaired in persons with ASD.

Research Products

• [Journal Article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder (2015)
  • Author(s): Itahashi T, Yamada T, Watanabe H, Nakamura M, Ohta H, Kanai C, Iwanami A, Kato N, Hashimoto R.
  • Journal Title: Mol Autism Volume: 6：30 Issue: 1 Pages: 1-14
  • DOI: 10.1186/s13229-015-0026-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A longitudinal functional neuroimaging study in medication-naive depression after antidepressant treatment. (2015)
  • Author(s): Tomioka H, Yamagata B, Kawasaki S, Pu S, Iwanami A, Hirano J, Nakagome K, Mimura M.
  • Journal Title: PLOS ONE Volume: 10 Issue: 3 Pages: e0120828-e0120828
  • DOI: 10.1371/journal.pone.0120828
  • Peer Reviewed / Open Access
• [Journal Article] P300 component of event-related potentials in persons with asperger disorder (2014)
  • Author(s): Iwanami A1, Okajima Y, Ota H, Tani M, Yamada T, Yamagata B, Hashimoto R, Kanai C, Takashio O, Inamoto A, Ono T, Takayama Y, Kato N
  • Journal Title: J Clin Neurophysiol Volume: 31 Issue: 5 Pages: 493-499
  • DOI: 10.1097/wnp.0000000000000080
  • Peer Reviewed
• [Journal Article] 発達障害と境界例 (2014)
  • Author(s): 岩波 明, 五十嵐 美紀, 森田 哲平
  • Journal Title: 精神科 Volume: 25 Pages: 16-21
• [Journal Article] アスペルガー障害における注意欠如・多動性障害の症状 (2014)
  • Author(s): 大野 泰正, 谷 将之, 山田 貴志, 橋本 龍一郎, 金井 智恵子, 高山 悠子, 岡島 由佳, 加藤 進昌, 岩波 明
  • Journal Title: 精神科 Volume: 24 Pages: 717-722
• [Journal Article] ADHDと注意機能 (2014)
  • Author(s): 岩波明
  • Journal Title: 精神科 Volume: 24 Pages: 182-188
• [Presentation] Reduced prefrontal activation in adult subjects with ADHD during a verbal fluency task (2017)
  • Author(s): Iwanami A, Okajima Y, Hayashi W
  • Organizer: 6th World Congress on ADHD
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2017-04-20
  • Int'l Joint Research
• [Presentation] Clinical characteristics of adults with ADHD (2017)
  • Author(s): Hayashi W, Arai G, Iwanami A
  • Organizer: 6th World Congress on ADHD
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2017-04-20
  • Int'l Joint Research
• [Presentation] The ability of theory of mind in adults with ADHD (2017)
  • Author(s): Arai G, Saga N, Iwanami A
  • Organizer: 6th World Congress on ADHD
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2017-04-20
  • Int'l Joint Research
• [Presentation] Assessing attentional functios in adults with ADHD (2017)
  • Author(s): Saga N, Arai G, Iwanami A
  • Organizer: 6th World Congress on ADHD
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2017-04-20
  • Int'l Joint Research
• [Presentation] NIRS findings in adults with ADHD (2015)
  • Author(s): Okajima Yuka, Morita Teppei, Tokumasu Takahiro, Saga Nobuyuki, Yamagata Bun, Iwanami Akira
  • Organizer: 5th World Congress on ADHD
  • Place of Presentation: グラスゴー
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] Clinical characteristics of adults with ADHD or ASD admitted to emergency psychiatric wards in Japan (2015)
  • Author(s): Morita Teppei, Yamada Hiroki, Tokumasu Takahiro, Saga Nobuyuki, Arai Goyu, Ikuse Daisuke, Iwanami Akira
  • Organizer: 5th World Congress on ADHD
  • Place of Presentation: グラスゴー
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] Similarity of subjective symptoms in persons with ADHD and Asperger’s disorder (2015)
  • Author(s): Tokumasu, Motira, Saga, Ikuse, Arai, Okajima, Iwanami
  • Organizer: 5th World Congress on ADHD
  • Place of Presentation: グラスゴー
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] Comorbid symptoms in adults with ADHD (2015)
  • Author(s): Saga, Morita, Tokumasu, Arai, Ikuse, Okajima, Iwanami
  • Organizer: 5th World Congress on ADHD
  • Place of Presentation: グラスゴー
  • Year and Date: 2015-05-28
  • Int'l Joint Research
• [Presentation] 成人ADHDにおける不安、抑うつ症状 (2014)
  • Author(s): 佐賀信之、森田哲平、徳増卓宏、五十嵐美紀、横井英樹、川久保由紀、岩波明
  • Organizer: 第34回日本精神科診断学会
  • Place of Presentation: 松山
  • Year and Date: 2014-11-13 – 2014-11-14
• [Presentation] 成人期ADHDの臨床 (2014)
  • Author(s): 岩波明
  • Organizer: 第34回日本精神科診断学会
  • Place of Presentation: 松山
  • Year and Date: 2014-11-13 – 2014-11-14
  • Invited
• [Book] 発達障害 (2017)
  • Author(s): 岩波明
  • Total Pages: 255
  • Publisher: 文藝春秋社
• [Book] 大人のADHD (2015)
  • Author(s): 岩波明
  • Total Pages: 236
  • Publisher: 筑摩書房
• [Book] 講談社 (2014)
  • Author(s): 岩波明
  • Total Pages: 190
  • Publisher: 発達障害を生きる