Development of the method for the quantitative assessment of myocardial perfusion MRI at 3T by using radio-water PET as a reference standard.

• Project/Area Number: 25461811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: ISHIDA Masaki 三重大学, 医学部附属病院, 助教 (10456741)
• Co-Investigator(Kenkyū-buntansha): KITAGAWA Kakuya 三重大学, 医学部附属病院, 講師 (50378353) ; SAKUMA Hajime 三重大学, 医学(系)研究科(研究院), 教授 (60205797)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 心筋血流 / 心筋パーフュージョンMRI / ガドリニウム造影剤 / 3テスラ / MRI / O-15水PET / 血流予備能 / 心筋血流PET / 心筋血流MRI

Outline of Final Research Achievements

We have optimized the procedure for the image acquisition of radio-water myocardial perfusion PET using 3D PET/CT system and 3T myocardial perfusion MRI and developed the method for the quantitative assessment of 3T myocardial perfusion MRI. The values of rest and stress myocardial blood flow obtained from 3D radio-water myocardial perfusion PET and 3T myocardial perfusion MRI were reasonable as compared with the values in literature. We continue the validation of the quantitative assessment of 3T myocardial perfusion MRI against 3D radio-water PET as a reference standard.

Research Products

• [Presentation] Comprehensive assessments of myocardial tissue kinetic parameters of K1, k2, MBF, lambda and ECV by using a synergistic quantitative analysis of first-pass myocardial perfusion MRI and pre-and post-contrast T1 mapping in patients with myocardial infarction. (2016)
  • Author(s): Akimasa Yamada, Masaki Ishida, Takashi Ichihara, Takahiro Natsume, Yoshitaka Goto, Mio Uno, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Hajime Sakuma
  • Organizer: ISMRM 2016 - 24th Annual Meeting & Exhibition
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Fermi function constrained deconvolution underestimates myocardial blood flow and myocardial perfusion reserve regardless of saturation correction of arterial input curve. (2016)
  • Author(s): Akimasa Yamada, Masaki Ishida, Takashi Ichihara,Takahiro Natsume, Tsuge Shinsuke, Yoshitaka Goto, Mio Uno, Motonori Nagata, Yasutaka Ichikawa, Kakuya Kitagawa, Hajime Sakuma
  • Organizer: SCMR 2016 19th Annual Scientific Sessions
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2016-01-27
  • Int'l Joint Research
• [Presentation] Absolute quantification of regional myocardial blood flow using O-15 water PET with and without attenuation correction (2015)
  • Author(s): Masaki Ishida, Yasutaka Ichikawa, Yoya Tomita, Akira Kamigiri, Hajime Sakuma
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] The effects of PET/CT misalignment on the quantification of myocardial blood flow in O-15 water myocardial PET/CT (2015)
  • Author(s): Yasutaka Ichikawa, Masaki Ishida, Yoya Tomita, Hajime Sakuma
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] 吸収補正を行わない15O水心筋血流PET/CTによる心筋血流定量評価は可能か (2014)
  • Author(s): 石田正樹、市川泰崇、冨田陽也、上桐章、伊藤瞬、佐久間肇
  • Organizer: 第54回日本核医学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] 心筋血流15O水PET/CT検査におけるtracer投与量/速度の最適化 (2014)
  • Author(s): 市川泰崇、石田正樹、冨田陽也、上桐章、伊東瞬、北川覚也、佐久間肇
  • Organizer: 第24回日本心臓核医学会総会・学術大会
  • Place of Presentation: 愛媛県県民文化会館
  • Year and Date: 2014-07-18 – 2014-07-19