Oxygen-enhanced dynamic MR imaging of cerebral vessels and cerebrospinal fluid.

• Project/Area Number: 25461815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: FUSHIMI Yasutaka 京都大学, 医学(系)研究科(研究院), 助教 (90639014)
• Co-Investigator(Renkei-kenkyūsha): OKADA Tomohisa 京都大学, 医学研究科, 准教授 (30321607) ; YAMAMOTO Akira 京都大学, 医学研究科, 助教 (60525567) ; KANAGAKI Mitsunori 京都大学, 医学研究科, 助教 (50378676) ; TOGASHI Kaori 京都大学, 医学研究科, 教授 (90135484)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: MRI / 酸素 / T1短縮効果 / 脳脊髄液 / 高空間分解能 / 高時間分解能 / 酸素吸入 / 高速撮影 / 脳血管 / 圧縮センシング / 酸素吸入イメージング / 脳脊髄液腔

Outline of Final Research Achievements

T1 shortening effect due to oxygen inhalation was studied in order to develop oxygen-enhanced MR imaging for cerebral vessels and cerebrospinal fluid. Dynamic signal change in cerebrospinal fluid (CSF) space was demonstrated at 3 tesla MRI. The signal in the subarachnoid space was more rapidly and more strongly observed than that in the ventricles. Our results suggested the soluble oxygen might diffuse directly into CSF space without entering choroid plexus, however it has been originally thought that choroid plexus is the only organ which produce CSF.

Research Products

• [Journal Article] Voxel Based Analysis of Surgical Revascularization for Moyamoya Disease: Pre- and Postoperative SPECT Studies. (2016)
  • Author(s): Fushimi Y, Okada T, Takagi Y, Funaki T, Takahashi JC, Miyamoto S, Togashi K.
  • Journal Title: PLoS One Volume: 11
  • NAID: 120005763395
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MP2RAGE for deep gray matter measurement of the brain: A comparative study with MPRAGE. (2016)
  • Author(s): Gosuke Okubo, Tomohisa Okada, Akira Yamamoto, Mitsunori Kanagaki, Yasutaka Fushimi, Tsutomu Okada, Katsuhisa Murata, and Kaori Togashi
  • Journal Title: J Magn Reson Imaging Volume: 43(1) Issue: 1 Pages: 55-62
  • DOI: 10.1002/jmri.24960
  • Peer Reviewed
• [Journal Article] Time-of-Flight Magnetic Resonance Angiography With Sparse Undersampling and Iterative Reconstruction: Comparison With Conventional Parallel Imaging for Accelerated Imaging. (2016)
  • Author(s): Yamamoto T, Fujimoto K, Okada T, Fushimi Y, Stalder AF, Natsuaki Y, Schmidt M, Togashi K.
  • Journal Title: Investigative Radiology Volume: 印刷中 Issue: 6 Pages: 372-378
  • DOI: 10.1097/rli.0000000000000221
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Magnetic resonance imaging of pituitary gland and postsphenoid ossification in fetal specimens (2016)
  • Author(s): Mehemed MT, Fushimi Y, Okada T, Kanagaki M, Yamamoto A, Okada T, Takakuwa T, Yamada S, Togashi K
  • Journal Title: American Journal of Neuroradiology Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Compressed sensing 3-dimensional time-of-flight magnetic resonance angiography for cerebral aneurysms: optimization and evaluation (2015)
  • Author(s): Yasutaka Fushimi, Koji Fujimoto, Tomohisa Okada, Akira Yamamoto, Toshiyuki Tanaka, Takayuki Kikuchi, Susumu Miyamoto, and Kaori Togashi
  • Journal Title: Investigative Radiology Volume: 51 Issue: 4 Pages: 228-235
  • DOI: 10.1097/rli.0000000000000226
  • NAID: 120005690118
  • Peer Reviewed
• [Journal Article] Quantitative Susceptibility Mapping at 3 T and 1.5 T: Evaluation of Consistency and Reproducibility. (2015)
  • Author(s): Takuya Hinoda, Yasutaka Fushimi, Tomohisa Okada, Koji Fujimoto, C. Liu, Akira Yamamoto, Tsutomu Okada, Aki Kido, and Kaori Togashi.
  • Journal Title: Invest Radiol Volume: 50(8) Issue: 8 Pages: 522-30
  • DOI: 10.1097/rli.0000000000000159
  • NAID: 120005601016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Grading meningioma: a comparative study of thallium-SPECT and FDG-PET. (2015)
  • Author(s): Okuchi, S., T. Okada, A. Yamamoto, M. Kanagaki, Y. Fushimi, T.Okada, M. Yamauchi, M. Kataoka, Y. Arakawa, J.C. Takahashi, S. Minamiguchi, S. Miyamoto, K. Togashi.
  • Journal Title: Medicine (Baltimore) Volume: 94 Issue: 6 Pages: e549-e549
  • DOI: 10.1097/md.0000000000000549
  • NAID: 120005997721
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of Periventricular Collaterals in Moyamoya Disease with Flow-sensitive Black-blood Magnetic Resonance Angiography: Preliminary Experience (2015)
  • Author(s): Funaki T, Fushimi Y, Takahashi JC, Takagi Y, Araki Y, Yoshida K, Kikuchi T, Miyamoto
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 3 Pages: 204-209
  • DOI: 10.2176/nmc.oa.2014-0360
  • NAID: 130004725011
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic oxygen-enhanced MRI of cerebrospinal fluid. (2014)
  • Author(s): Mehemed TM, Fushimi Y, Okada T, Yamamoto A, Kanagaki M, Kido A, Fujimoto K, Sakashita N, Togashi K.
  • Journal Title: PLoS One Volume: 23 Issue: 6 Pages: e100723-e100723
  • DOI: 10.1371/journal.pone.0100723
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 3D dynamic pituitary MR imaging with CAIPIRINHA: initial experience and comparison with 2D dynamic MR imaging (2014)
  • Author(s): 5.Fushimi Y, Okada T, Kanagaki M, Yamamoto A, Kanda Y, Sakamoto R, Hojo M, Takahashi JC, Miyamoto S, Togashi K.
  • Journal Title: Eur J Radiol. Volume: 83 Issue: 10 Pages: 1900-1906
  • DOI: 10.1016/j.ejrad.2014.06.018
  • NAID: 120005606118
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Clinical Evaluation of TOF-MRA with Sparse Undersampling and Iterative Reconstruction (Sparse TOF) for Cerebral Aneurysms. (2016)
  • Author(s): 3.Yasutaka Fushimi, Tomohisa Okada, Akira Yamamoto, Takayuki Yamamoto, Aurelien Stalder, Michaela Schmidt, Yutaka Natsuaki, and Kaori Togashi.
  • Organizer: ISMRM 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Quantitative Susceptibility Mapping between 3T and 1.5T: Magnetic Field Difference and Reproducibility. (2015)
  • Author(s): Takuya Hinoda, Yasutaka Fushimi, Tomohisa Okada, Koji Fujimoto, Akira Yamamoto, Tsutomu Okada, Aki Kido, Kaori Togashi.
  • Organizer: ESMRMB 2015
  • Place of Presentation: イギリス、エジンバラ
  • Year and Date: 2015-10-01
  • Int'l Joint Research
• [Presentation] Correlation between proton MR spectroscopy and amide proton transfer imaging for brain tumors Correlation between proton MR spectroscopy and amide proton transfer imaging for brain tumors. (2015)
  • Author(s): Yasutaka Fushimi, Akihiko Sakata, Tomohisa Okada, Kyoko Takakura, Aki Kido, Naotaka Sakashita, Kaori Togashi.
  • Organizer: EMSRMB 2015
  • Place of Presentation: イギリス、エジンバラ
  • Year and Date: 2015-10-01
  • Int'l Joint Research
• [Presentation] Brain Morphometry Reproducibility Analysis between Longitudinal and Cross-sectional Processing. (2015)
  • Author(s): Naoto Maruguchi, Yasutaka Fushimi, Tomohisa Okada, Koji Fujimoto1, Takuya Hinoda1, Akira Yamamoto, Tsutomu Okada, Aki Kido, Naotaka. Sakashita, Kaori Togashi.
  • Organizer: EMSRMB 2015
  • Place of Presentation: イギリス、エジンバラ
  • Year and Date: 2015-10-01
  • Int'l Joint Research
• [Presentation] 3Tテスラ・1.5TテスラMRIにおける定量的磁化率マッピング（QSM）の再現性に関する検討 (2015)
  • Author(s): 日野田卓也、伏見育崇、岡田知久、山本憲、岡田務、Taha M Mehemed、奥知左智、坂田昭彦、百々俊樹、大久保豪佑、山内盛敬、山本貴之、福富光、高倉京子、藤本晃司、木戸晶、富樫かおり
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京、東京ドームホテル
  • Year and Date: 2015-09-10
• [Presentation] 自作ファントムを用いた定量的磁化率マッピングの基礎的検討 (2015)
  • Author(s): 高倉京子、伏見育崇、日野田卓也、岡田知久、木戸晶、富樫かおり
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京、東京ドームホテル
  • Year and Date: 2015-09-10
• [Presentation] Optimization of Tuning Parameters for NESTA Algorithm in Reconstruction of 3D TOF-MRA (2015)
  • Author(s): Yasutaka Fushimi, Koji Fujimoto, Tomohisa Okada, Akira Yamamoto, Takayuki Yamamoto, Tai Akasaka, Kei Sano, Toshiyuki Tanaka, Kaori Togashi.
  • Organizer: ISMRM 2015
  • Place of Presentation: カナダ、トロント
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Dynamic oxygen-enhanced MRI of cerebrospinal fluid: IR FASE vs. FASE (2014)
  • Author(s): Yasutaka Fushimi, Tomohisa Okada, Taha M. Mehemed, Akira Yamamoto, Mitsunori Kanagaki, Aki Kido, Koji Fujimoto, Naotaka Sakashita, Kaori Togashi
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: イタリア、ミラノ
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] 3D dynamic pituitary MR imaging with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) (2014)
  • Author(s): 20.Yasutaka Fushimi, Tomohisa Okada, Mitsunori Kanagaki, Akira Yamamoto, Yumiko Kanda, Ryo Sakamoto, Masato Hojo, Jun C. Takahashi, Susumu Miyamoto, Kaori Togashi
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: イタリア、ミラノ
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Dynamic oxygen-enhanced MRI of cerebrospinal fluid: IR FASE vs. FASE (2014)
  • Author(s): Yasutaka Fushimi, Tomohisa Okada, Taha M. Mehemed, Akira Yamamoto, Mitsunori Kanagaki, Aki Kido, Koji Fujimoto, Naotaka Sakashita, Kaori Togashi
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: イタリア、ミラノ市
• [Presentation] Dynamic Oxygen-Enhanced MRI of Cerebrospinal Fluid: Inversion Recovery Fast Advanced Spin Echo (IR-FASE) Vs. FASE. (2013)
  • Author(s): Taha M. Mehemed, Yasutaka Fushimi, Tomohisa Okada, Akira Yamamoto, Mitsunori Kanagaki, Ryo Sakamoto, Emiko Morimoto, Sachi Okuchi, Satoshi Nakajima, Akihiko Sakata, Toshiki Dodo, Koji Fujimoto, Aki Kido, Naotaka Sakashita, Kaori Togashi.
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島県徳島市
• [Presentation] Dynamic Oxygen-Enhanced MRI of Cerebro-Spinal Fluid: Inversion Recovery Fast Advanced Spin Echo (IR-FASE) Vs. FASE. (2013)
  • Author(s): T.M. Mehemed, Y. Fushimi, T. Okada, A. Yamamoto, M. Kanagaki, R. Sakamoto, E., Morimoto, S. Okuchi, S. Nakajima, H. Yamada, A. Sakata, T. Dodo, T. Kakigi, Y. Kanazawa, K., Takakura, K. Fujimoto, A. Kido, N. Sakashita, K. Togashi.
  • Organizer: 30th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology
  • Place of Presentation: フランス、トゥルーズ
• [Patent(Industrial Property Rights)] 磁気共鳴イメージング装置及び画像処理装置 (2013)
  • Inventor(s): 伏見育崇、坂下尚孝
  • Industrial Property Rights Holder: 伏見育崇、坂下尚孝
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-20