DNA damage induced by radiation exposure at CT
| Project/Area Number |
25461825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hiroshima University |
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Principal Investigator |
AWAI Kazuo 広島大学, 医歯薬保健学研究院(医), 教授 (30294573)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Yukiko 広島大学, 病院(医), 講師 (10397911)
Ishida Mari 広島大学, 医歯薬保健学研究院, 講師 (30359898)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | CT / DNA / X線被曝 / gamma-H2Ax / X線被ばく / 二重鎖切断 / γ-H2AX / 染色体異常 / 放射線被ばく / 医療被ばく / 低線量被ばく |
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| Outline of Final Research Achievements |
We investigated whether physical exposure parameters such as CTDI, DLP, and SSDE are predictive of the level of radiation-induced DNA damage. In our in vitro study we scanned a phantom containing blood samples from 5 healthy volunteers at CTDI 0-, 50-, 100-, and 150 mGy. In the in vivo study we enrolled 45 patients who underwent cardiac CT before ablation therapy. We obtained their blood samples before- and 15 minutes after CT and before ablation therapy. The number of γ-H2AX foci in lymphocytes was measured both studies. DNA damage was induced by radiation exposure from cardiac CT. There was a significant correlation between the physical exposure parameters and the induction of γ-H2AX. Our data suggest that the actual effect of CT radiation on the human body can be estimated by using physical exposure parameters.
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Report
(4 results)
Research Products
(5 results)
