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Development of function-preserving embolization for large and amorphous peripheral aneurysm

Research Project

Project/Area Number 25461885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionSapporo Medical University

Principal Investigator

Hirokawa Naoki  札幌医科大学, 医学部, 講師 (30404718)

Co-Investigator(Kenkyū-buntansha) USAMI Yoko  札幌医科大学, 医学部, 研究員 (20572530)
SAITOH Masato  札幌医科大学, 医学部, 助教 (70551109)
OKUDA Hiroki  札幌医科大学, 医学部, 研究員 (40753140)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsIVR / 塞栓術 / コイル / 動脈瘤 / 腹部 / 末梢 / 末梢動脈瘤 / インターベンショナルラジオロジー / 腹部動脈瘤 / 再発防止 / 器質化 / 内皮形成 / 形状保持 / PGLAコイル / ベアコイル / 毛付きコイル / 器質化コイル
Outline of Final Research Achievements

To reduce the number of coils and to avoid re-perfusion in coil embolization for aneurysm, we believe that preventing blood flow with membrane formation at the aneurysmal neck, keeping coil formation, and reinforcing coil scaffold with biological substance, are needed. For this purpose, we used both biological and fibered coils for peripheral aneurysms. Intimal formation at aneurismal neck was thicker with both biological and fibered coils. The amount of fibrous organization was not different with various coils. However, the multinucleated giant cell formation was more in a combination of biological and fibered coils. In physical experiment, platinum 3D bare coils, which have no biological effect, became unstable immediately after coiling. Actually, the coil embolization was performed with a combination of biological, fibered, and 3D bare coils in 13 abdominal aneurysms. Coil formation remained stable and re-perfusion did not occur in all in spite of reducing coil occupation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015

All Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Strategic Embolization Combined with 3D, Bioactive, and Fibered Coils for Intra-Abdominal Aneurysms2015

    • Author(s)
      Hiroki Okuda, Naoki Hirokawa, Yoko Usami, Masato Saito, Nana Natsume, Yuuki Hukushima, Toshio Gocho, Koichi Sakata
    • Organizer
      JSIR, ISIR & APCIO 2015
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県・宮崎市)
    • Year and Date
      2015-05-28 – 2015-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Histopathologic differences of experimental aneurysms treated with bare, fibered, and PGLA microcoils2015

    • Author(s)
      Yoko Usami, Naoki Hirokawa, Masato Saitoh, Hiroki Okuda, Koh-ich Sakata, Tadashi Hasegawa
    • Organizer
      JSIR, ISIR & APCIO 2015
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県・宮崎市)
    • Year and Date
      2015-05-28 – 2015-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Strategic Embolization Combined with 3D,Bioactive,and Fibered Coils for Intra-Abdominal Aneurysms-aiming for functional preservation and small coil number-2015

    • Author(s)
      Hiroki Okuda,Naoki Hirokawa,Yoko Usami,Masato Saito,Nana Natsume,Yuuki Hukushima, Toshio Gocho,Koichi Sakata
    • Organizer
      JSIR & ISIR 2015
    • Place of Presentation
      宮崎シーガイア(宮崎県宮崎市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Strategic Embolization Combined with 3D, Bioactive, and Fibered Coils for Intra-Abdominal Aneurysms2015

    • Author(s)
      Hiroki Okuda, Naoki Hirokawa, Yoko Usami, Masato Saito, Nana Natsume, Yuuki Hukushima, Toshio Gocho, Koichi Sakata
    • Organizer
      第74回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜)
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Histopathologic differences of experimental aneurysms treated with bare, fibered, and PGLA microcoils2015

    • Author(s)
      Yoko Usami, Naoki Hirokawa, Masato Saitoh, Hiroki Okuda, Koh-ich Sakata, Tadashi Hasegawa
    • Organizer
      第74回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜)
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 腹部動脈瘤に対するコイル塞栓術の成績-3次元並びにPGLAコイル,Fiberedコイルを用いた塞栓-2015

    • Author(s)
      奥田洋輝,廣川直樹,宇佐見陽子,齋藤正人,夏目奈奈,福島悠希,後町俊夫,坂田耕一
    • Organizer
      第63回北海道血管造影Interventional Radiology研究会
    • Place of Presentation
      北海道大学学術交流会館(北海道・札幌市)
    • Year and Date
      2015-02-14
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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