Progression for liver failure with Near-Infrared Fluorescence Imaging

• Project/Area Number: 25461970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hokkaido University
• Principal Investigator: Tanaka Eiichi 北海道大学, 医学(系)研究科(研究院), 客員研究員 (60374279)
• Co-Investigator(Kenkyū-buntansha): EBIHARA YUUMA 北海道大学, 大学病院, 助教 (50632981) ; SCHINOHE TOSHIAKI 北海道大学, 医学(系)研究科(研究院), 准教授 (70374353) ; NOJI TAKEHIRO 北海道大学, 大学病院, 特任助教 (10739296)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ICG / 肝不全 / 肝機能 / 近赤外光 / 術中イメージング

Outline of Final Research Achievements

Near-infrared (NIR) fluorescence imaging might offer a promising modality to evaluate liver reserve, as this method enables quantitative assessment of the fluorescent signal from indocyanine green (ICG) in regions of interest on the liver surface.We performed clinical research. ICG was injected intravenously and fluorescent intensity (FI) and signal-to-background ratio (SBR) in the lateral segment of the liver were assessed for 15 min. Results: A significant correlation was seen between ICGK and the rate of change of FI up to 15 min.
Conclusion: Intraoperative NIR fluorescence imaging using ICG may be useful as a new method for assessing liver function.