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Analysis of genetic alterations in thyroid cancer in the young population.

Research Project

Project/Area Number 25461989
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionFukushima Medical University

Principal Investigator

Fukushima Toshihiko  福島県立医科大学, 医学部, 准教授 (20336457)

Co-Investigator(Kenkyū-buntansha) SUZUKI SHINICHI  福島県立医科大学, 器官制御外科, 教授 (70235951)
HAYASE SUGURU  福島県立医科大学, 器官制御外科, 助教 (00583387)
隈元 謙介  福島県立医科大学, 医学部, 助教 (60457778)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords甲状腺癌 / 小児甲状腺癌 / 甲状腺乳頭癌 / 小児甲状腺
Outline of Final Research Achievements

We investigated the presence of cancer driver mutations in 67 cases of thyroid cancer. Written informed consent was obtained from the parents. We detected BRAF V600E in 43 cases (63%). N, H, K-RAS mutations were not detected. These results were equal to the results in the adult study and different from post-Chernobyl thyroid cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] BRAFV600E mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl.2015

    • Author(s)
      Mitsutake N, Fukushima T, Matsuse M, Rogounovitch T, Saenko V, Uchino S, Ito M, Suzuki K, Suzuki S, Yamashita S
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 16976-16976

    • DOI

      10.1038/srep16976

    • NAID

      120006986823

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 小児甲状腺癌におけるBRAF異常2015

    • Author(s)
      福島俊彦中村泉鈴木聡中野恵一鈴木眞一
    • Organizer
      第58回日本甲状腺学会
    • Place of Presentation
      福島市
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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