| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, we explore DNA methylation alterations in non-cancer tissues to evaluate the susceptibility of cancer. Methylation alterations are observed in both cancer and non-cancer tissues, so we elucidate the levels in non-cancer tissues to link with the predisposition of cancer or detection of early cancer. We identified methylation alterations in some genes decreased in cancer tissues, and explore the levels of methylation in these genes in non-cancer tissues. In ulcerative colitis, we showed that methylation alteration in non-cancer tissues could be a useful biomarker for the predisposition of colitic-cancer. Comprehensive analysis of DNA methylation array in colon cancer revealed that methylation alterations underlying colon cancer development are shared between cancer and adenomas.
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