Role of neural crest cells in bicuspic aortic valve
Project/Area Number |
25462147
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular surgery
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Research Institution | Yamazaki Gakuen University (2015) Tokyo Women's Medical University (2013) |
Principal Investigator |
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Research Collaborator |
NAGAO Hiroaki 東京女子医科大学, 医学部, 技師
MAEDA Kazuhiro 東京女子医科大学, 医学部, 大学院生
SEYA Daiki 東京大学, 大学院医学研究科, 大学院生
MARUYAMA Kazuaki 東京大学, 大学院医学研究科, 大学院生
KURIHARA Hiroki 東京大学, 大学院医学研究科, 教授
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 大動脈弁 / 二弁性大動脈弁 / 神経堤細胞 / 1細胞解析 / 二尖弁 / 1細胞解析 / Semapholin3E / 先天性心疾患 |
Outline of Final Research Achievements |
The aortic valve which consists of three valve leaflets prevents regurgitant blood flow at the outflow tract of the left ventricle. Bicuspid aortic valve is the most common congenital heart defect, occurring in 0.5% to 2% of the general population, with a higher prevalence in men. Mature aortic valves are stratified into extracellular matrix layers rich in elastin (ventricularis), proteoglycan (spongiosa) and collagen (fibrosa). Formation of the aortic valve is involved in endocardial cells, second heart field derived cells, and neural crest derived cells. In our research, postotic and preotic neural crest cells were shown distinctive patterns in the aortic valve leaflets. And we confirmed that neural crest cells were involved in the development of the ascending aorta.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.2015
Author(s)
Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Neme N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 6853-6853
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.2015
Author(s)
Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H
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Journal Title
Developmental Biology
Volume: 15
Issue: 2
Pages: 162-174
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.2015
Author(s)
Moriya M, Inoue S, Miyagawa-Tomita S, Nakashima Y, Oba D, Niihori T, Hashi M, Ohnishi H, Kure S, Matsubara Y, Aoki Y.
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Journal Title
Hum Mol Genet.
Volume: 24
Issue: 25
Pages: 7349-7360
DOI
Related Report
Peer Reviewed
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[Journal Article] Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.2013
Author(s)
Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T
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Journal Title
Mech Dev.
Volume: 130
Issue: 11-12
Pages: 519-31
DOI
Related Report
Peer Reviewed
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[Presentation] Semaphorin 3E-PlexD1 signaling regulate the proper coronary artery development.2016
Author(s)
Kazuaki Maruyama, Sachiko Miyagawa-Tomit , Yuichiro Arima, Daiki Seya, Kazuaki Naemura, Akiyoshi Uemura, Yutaka Yoshida, Mann Fanny, Yukiko Kurihara, Hiroki Kurihara
Organizer
Weinstein Cardiovascular Development and Regeneration Conference2016
Place of Presentation
Darham, USA
Year and Date
2016-05-19
Related Report
Int'l Joint Research
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[Presentation] Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype.2016
Author(s)
Shin-ichi Inoue, Mitsuji Moriya, Sachiko Miyagawa-Tomita, Yasumi Nakashima, Daiju Oba, Tetsuya Niihori, Misato Hashi, Hiroshi Ohnishi, Shigeo Kure, Yoichi Matsubara and Yoko Aoki
Organizer
The 13th International Congress of Human Genetics
Place of Presentation
Kyoto International Conference Center, Kyoto
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Therapeutic research in a mouse model of cardio-facio-cutaneous syndrome.2016
Author(s)
Daiju Oba, Shin-ichi Inoue, Mitsuji Moriya, Yusuke Watanabe, Tetsuya Niihori, Sachiko Miyagawa-Tomita, Shigeo Kure, Toshihiko Ogura, Yoichi Matsubara, Yoko Aoki
Organizer
The 13th International Congress of Human Genetics
Place of Presentation
Kyoto International Conference Center, Kyoto
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] がん原遺伝子BRAFの機能獲得性変異は先天性異常を引き起こす2015
Author(s)
井上晋一1, 守谷充司1,2, 宮川-富田幸子3, 中嶌八隅4, 大場大樹1, 新堀哲也1, 橋美里5, 大西浩史5, 呉繁夫2, 松原洋一1,6, 青木洋子1
Organizer
第38回日本分子生物学会年会
Place of Presentation
神戸ポートアイランド(兵庫県神戸市)
Year and Date
2015-12-01
Related Report
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[Presentation] The preotic neural crest directly contributes to the coronary arteries2013
Author(s)
Sachiko Miyagawa-Tomita, Yuichiro Arima, Kazuhiro Maeda, Rieko Asai, Ki-Sung Kim, Daiki Seya, Maryline Minoux, Filippo M. Rijli, Koichi Nishiyama, Yasunobu, Uchijima, Toshio Nakanishi1, Hisao Ogawa, Yukiko Kurihara and Hiroki Kurihara
Organizer
Weinstein Cardiovascular Development Conference
Place of Presentation
Tucson, AZ, USA
Related Report
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[Presentation] The preotic neural crest directly contributes to the coronary arteries
Author(s)
Miyagawa-Tomita S, Arima Y, Maeda K, Asai R, Kim KS, Seya D, Minoux M, Rijli FM, Nishiyama K, Uchijima Y, Nakanishi T, Ogawa H, Kurihara Y, Kurihara H
Organizer
東京女子医科大学学内研究交流セミナー
Place of Presentation
東京
Related Report
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