| Project/Area Number |
25462154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
蒲生 修治 九州保健福祉大学, 薬学部, 准教授 (20273930)
金井 祐 九州保健福祉大学, 薬学部, 助教 (20551295)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 冠動脈バイパス手術 / 糖尿病 / 伏在静脈 / 内胸動脈 / スパズム / セロトニン / アンジオテンシンⅡ / 心バイパス手術 / 冠動脈れん縮 / セロトニン受容体 / ミオシン軽鎖 / ﾐｵｼﾝ軽鎖 |
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| Outline of Final Research Achievements |
Bypass grafts harvested from Diabetes mellitus (DM) patients tend to spasm after implantation into coronary circulation. Our mine findings are that ①angiotensin II (Angll)- and 5-HT-induced constrictions of human endothelium-denuded saphenous vein (SV) and internal thoracic artery (ITA) were significantly greater in the DM group than in the non-DM group. ②The protein level of the Angll and 5-HT2A receptors in the membrane fraction of ITA smooth muscle cells were significantly increased in the DM group compared with the non-DM group. ③However, only Angll receptor, but not 5-HT2A receptor, in the membrane fraction of human SV smooth muscle cells was significantly increased in the DM group. Our findings suggest that the molecular mechanisms for 5-HT-induced hyper reactivity in an arterial graft are different from those in a venous graft.
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