| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
A purpose of this study is to promote the neural regeneration of the cerebral infarction lesion. For acute cerebral infarction, we give indirect bypass and GCSF. We obtain bone marrow stromal cells at the same time. It is intended to supplement of angiogenesis and the neurotrophic factor for the acute phase. To cerebral infarction of the chronic stage, we hoped that bone marrow stromal cell became easy to reach it through a new route made with angiogenesis.
Indirect bypass and GCSF administration were provided for MCAO(90min). We injected bone marrow stromal cell into temporal muscle. As a result, we confirmed that transplant cells did colonization around a cerebral infarction lesion. However, in improvement of the neurologic function, we did not demonstrate a significant difference. A further study is necessary.
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