Radiation therapy for functional neuronal disorders: application of selective neuronal death using microbeam X-ray

• Project/Area Number: 25462259
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kobe University
• Principal Investigator: Kondoh Takeshi 神戸大学, 医学(系)研究科(研究院), 研究員 (50273769)
• Co-Investigator(Kenkyū-buntansha): Mizukawa Katsu 神戸大学, 医学部附属病院, 助教 (80403260) ; Kohmura Eiji 神戸大学, 医学(系)研究科(研究院), 教授 (30225388)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: microbeam x=ray / functional disease / neuronal disorders / selective neuronal death / 高輝度放射光 / X線CT / マイクロビーム / 放射線治療 / 高輝度放射光施設 / 放射線壊死 / ラット

Outline of Final Research Achievements

Coplanar micro mili meter beam X-ray irradiation on the central nervous system demonstrated that selective lesioning of neuronal pathway can be made while anatomical structures were maintained. This application is quite unique, in contrast to conventional stereotactic radiation therapy causing tissue necrosis. It enables that specific blockade of excitatory pathway and preservation of normal neuronal function in the surrounding area. It is also applicable repeatedly. Clinical applications for the treatment of drug-resistant epilepsy and advanced Parkinson disease are expected in the future.

Research Products

• [Journal Article] Gamma Knife surgery for patients with jugular foramen schwannomas: a multiinstitutional retrospective study in Japan. (2016)
  • Author(s): Hasegawa T, Kato T, Kida Y, Sasaki A, Iwai Y, Kondoh T, Tsugawa T, Sato M, Sato M, Nagano O, Nakaya K, Nakazaki K, Kano T, Hasui K, Nagatomo Y, Yasuda S, Moriki A, Serizawa T, Osano S, Inoue A.
  • Journal Title: J Neurosurg. Volume: 22 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Radiosurgery for symptomatic cavernous malformations: A multi-institutional retrospective study in Japan (2015)
  • Author(s): Kida Y, Hasegawa T, Iwai Y, Shuto T, Satoh M, Kondoh T, Hayashi M.
  • Journal Title: Surg Neurol Int. Volume: 6(Suppl 5) Issue: 6 Pages: 249-249
  • DOI: 10.4103/2152-7806.157071
  • Peer Reviewed
• [Presentation] Microangiography から Microbeam irradiation:臨床医としての 10 年の研究 (2014)
  • Author(s): 近藤 威
  • Organizer: Pring-8利用ワークショップ --SPring-8とユーザーのさらなる連携を目指して--
  • Place of Presentation: 兵庫県佐用郡佐用町
  • Invited