| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In order to investigate modification of general anesthetic actions in the presence of psychotropic medications, we have studied the effects of general anesthetics on synaptic transmission in the absence or presence of psychotropic agents in the rat amygdalo-hippocampal slices. Our results indicated that psychotropic agent, valproic acid, modified the amygdala neural input and enhanced the attenuation of hippocampal synaptic transmission by general anesthetic, thiopental. In case of anesthetic managements of psychotropic medicated patients, anesthesiologists should pay attention to anesthetic depth because of destabilization of general anesthetic actions in the central nervous systems.
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