Investigating whether D-serine is associated with delayed paraplegia after spinal cord ischemia in mice
| Project/Area Number |
25462406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKINOHANA Manabu 琉球大学, 大学院医学研究科, 教授 (20274897)
OSHIRO Masakatsu 琉球大学, 医学部附属病院, 助教 (00315483)
NAKAMURA Seiya 琉球大学, 大学院医学研究科, 准教授 (00363680)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Dセリン / 虚血性脊髄障害 / 対麻痺 / グルタミン酸 / 遅発性対麻痺 / リン酸化ERK1/2 / p38 / 遅発性麻痺 |
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| Outline of Final Research Achievements |
The investigating whether D-serine, NMDA receptor coagonist, is associated with the neuropathological mechanism of delayed paraplegia after spinal cord ischemia in mice was done. Expression of D-serine as well as serine racemase, D-serine synthesis enzyme, was increasing in the spinal cord 24hr after ischemia. However, werstern blotting analysis showed no increase of ERK1/2 in the spinal cord 24hr after spinal cord ischemia. Of interesting, mice deficient SR (SR knockout mice) showed delayed paraplegia, same as wild type mice, after spinal cord ischemia . Based on these results, neither D-serine or SR expression after spinal cord ischemia might be associated with delayed paraplegia after spinal cord ischemia in mice.
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Report
(3 results)
Research Products
(3 results)
