Mechanism of postoperative cognitive dysfunction-Examination from neuroinflammation
| Project/Area Number |
25462420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Morimoto Yuji 北海道大学, 医学研究科, 教授 (00250457)
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| Co-Investigator(Kenkyū-buntansha) |
神谷 温之 北海道大学, 医学研究科, 教授 (10194979)
橘 かおり 北海道大学, 大学病院, 医員 (50374468)
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| Research Collaborator |
HASEGAWA Kan
HOSHINO Koji
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 神経炎症 / 認知機能障害 / シナプス可塑性 / 敗血症関連脳症 / インターロイキン / 海馬 / サイトカイン / 敗血症 / 術後認知障害 |
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| Outline of Final Research Achievements |
To investigate the effects of IL-1beta on synaptic plasticity, we examined long-term potentiation (LTP) electrophysiologically in different hippocampal regions in acute mouse brain slices. Our results demonstrated that IL-1beta exerted variable effects on LTP at different kinds of synapses, indicating that IL-1beta had synapse-specific effects on hippocampal synaptic plasticity.
Next, we investigated the effects of minocycline (MINO) on LTP in the hippocampus in a cecal ligation and puncture (CLP) mouse model. We have provided the evidence that MINO prevents impaired LTP related to sepsis-induced encephalopathy in the mouse hippocampus, and that mechanisms associated with IL-1 receptor activity may be involved.
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Report
(4 results)
Research Products
(3 results)
