| Project/Area Number |
25462455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Nishihara Makoto 愛知医科大学, 医学部, 教授 (60380325)
Ushida Takahiro 愛知医科大学, 医学部, 教授 (60304680)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | パルス高周波法神経根ブロック / A-δ線維 / 鎮痛メカニズム / パルス高周波法（ＰＲＦ）神経ブロック / パルス高周波法（ＰＲＦ）神経根ブロック |
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| Outline of Final Research Achievements |
Not only dorsal root ganglion pulsed radiofrequency but also intravenous magnesium and lidocaine have been used for the management of intractable pain individually or in combination and a study reported the sound effect of the intravenous combination on neuralgia when antiepileptic drugs failed. One of the aims is to see how a combination of intravenous magnesium and lidocaine influenced electrically-evoked responses of peripheral A-δ and A-β nerve fibers at non-affected and affected areas. Although three patients with neuralgia experienced sound pain relief, the combination had a different effect on peripheral A-δ and A-β nerve fibers at non-affected and affected areas in each patient. The second aim is to see how dorsal root ganglion pulsed radiofrequency influenced peripheral A-δ and A-β nerve fibers at non-affected and affected areas in patients with vertebral metastatic pain. Now, the number of the study sample has been increasing.
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