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A Kit Ligand, Stem Cell Factor as a Possible Mediator Inducing Overactive Bladder

Research Project

Project/Area Number 25462521
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

Kubota Yasue  名古屋市立大学, 医学(系)研究科(研究院), 講師 (00381830)

Co-Investigator(Kenkyū-buntansha) SASAKI Shoichi  名古屋市立大学, 大学院医学研究科, 准教授 (50225869)
HAMAKAWA Takashi  名古屋市立大学, 大学院医学研究科, 助教 (40595394)
SIBATA Yasuhiro  名古屋市立大学, 大学院医学研究科, 助教 (10534745)
IMURA Makoto  名古屋市立大学, 大学院医学研究科, 研究員 (00551269)
TAKADA Masa  名古屋市立大学, 大学院医学研究科, 研究員 (60468254)
KOHRI Kenjiro  名古屋市立大学大学, 学長 (30122047)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords過活動膀胱 / Kit / 幹細胞因子 / バイオマーカー / SCF / c-kit
Outline of Final Research Achievements

In the gastrointestinal tract, interstitial cells of Cajal (ICCs) act as primary pacemaker cells to generate slow wave activity, and play a fundamental role in the transmission of signals from enteric neurons to smooth muscle cells. ICCs have been also identified in the urinary bladder. KIT is used as an identification marker of ICCs, and KIT-positive ICCs are located throughout the bladder wall.
They may be involved in signal transmission between smooth muscle bundles, from efferent nerves to smooth muscles, and from urothelium to afferent nerves. Not only disturbance of spontaneous contractility caused by the altered dertusor ICC signal transduction between nerves and smooth muscle cells but also disturbance of signal transduction between urothelial cells and sensory nerves via suburethelial ICC may induce overactive bladder (OAB).
The blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment, although further study will be needed.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (8 results) (of which Open Access: 3 results,  Peer Reviewed: 5 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] 特集 夜間頻尿を診る-これを読めば解決! Ⅳ.診断と治療 前立腺肥大症に伴う夜間頻尿。2015

    • Author(s)
      濱川 隆、窪田 泰江、佐々木 昌一
    • Journal Title

      臨床泌尿器科

      Volume: 69 Pages: 475-479

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 過活動膀胱におけるSCF-Kitシグナル伝達系の機能解析と分子標的治療薬の開発。2015

    • Author(s)
      窪田 泰江、佐々木 昌一、濱川 隆
    • Journal Title

      臨床薬理の進歩

      Volume: 83 Pages: 632-640

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 実地内科医の治療と専門医との連携の実際と留意点 泌尿器科疾患 過活動膀胱2015

    • Author(s)
      窪田 泰江
    • Journal Title

      Medical Practice

      Volume: 32 Pages: 1445-1450

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 特集 尿と血液からわかる腎臓病 【診断】尿異常と結石2015

    • Author(s)
      窪田 泰江、安井 孝周
    • Journal Title

      腎と透析

      Volume: 79 Pages: 609-612

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Increased crystal-cell interaction in vitro under co-culture of renal tubular cells and adipocytes by in vitro co-culture paracrine systems simulating metabolic syndrome.2014

    • Author(s)
      Ichikawa J, Okada A, Taguchi K, Fujii Y, Zuo L, Niimi K, Hamamoto S, Kubota Y, Umemoto Y, Itoh Y, Yasui T, Kawai N, Tozawa K, Kohri K.
    • Journal Title

      Urolithiasis.

      Volume: 42 Issue: 1 Pages: 17-28

    • DOI

      10.1007/s00240-013-0612-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Laparoendoscopic Single-Site Partial Nephrectomy Without Hilar Clamping Using a Microwave Tissue Coagulator.2014

    • Author(s)
      Kawai Noriyasu, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      Journal of Endourology

      Volume: 28(2) Issue: 2 Pages: 184-190

    • DOI

      10.1089/end.2013.0135

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcomes of robot-assisted laparoscopic prostatectomy with a posteror approach to the seminal vesicle in 150 Japanese patients2013

    • Author(s)
      Yasui Takahiro, Tozawa Keiichi, Kurokawa Satoshi, Umemoto Yukihiro, Okada Atsushi, Mizuno Kentaro, Kubota Yasue, Kawai Noriyasu, Sasaki Shoichi, Hayashi Yutaro, Takeuchi Mitsuru, Shibamoto Yuta, Takahashi Satoru, Kojima Yoshiyuki, Kohri Kenjiro
    • Journal Title

      NAGOYA MEDICAL JOURNAL

      Volume: 53 Pages: 11-25

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kidney stone formation is positively associated with conventional risk factors for coronary heart disease in Japanese men.2013

    • Author(s)
      Ando R, Nagaya T, Suzuki S, Takahashi H, Kawai M, Okada A, Yasui T, Kubota Y, Umemoto Y, Tozawa K, Kohri K.
    • Journal Title

      Journal of urology

      Volume: 189 Issue: 4 Pages: 1340-1346

    • DOI

      10.1016/j.juro.2012.11.045

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 過活動膀胱治療における服薬状況および患者の満足度に関するアンケート調査2015

    • Author(s)
      窪田 泰江、濱川 隆、早瀬 麻沙、梅本 幸裕、河合 憲康、佐々木 昌一、郡 健二郎、安井 孝周
    • Organizer
      第65回日本泌尿器科学会中部総会
    • Place of Presentation
      長良川国際会議場、岐阜都ホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interleukin 18 may induce changes in the prostatic stromal components via thrombospondin 1 production in a newly developed rat benign prostatic hyperplasia model2015

    • Author(s)
      Hamakawa Takashi, Sasaki Shoichi, Kubota Yasue, Kohri Kenjiro, Yasui Takahiro
    • Organizer
      ICS 2015
    • Place of Presentation
      Montreal(Canada)
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ロボット支援前立腺全摘除術が及ぼす夜間頻尿への影響2015

    • Author(s)
      濱川 隆、佐々木 昌一、高田 麻沙、窪田 泰江、河合 憲康、戸澤 啓一、郡 健二郎、安井 孝周
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      京王プラザホテル札幌(北海道札幌市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Can sperm be retrieved in men with an FSH level less than 10 mlU/mL? A study of aspermic patients with an FSH level less than 10mlU/mL.2015

    • Author(s)
      Umemoto Yukihiro, Sasaki Shoichi, Iwatsuki Shoichiro, Kubota Yasue, Kubota Hiroki, Kamiya Hiroyuki, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      IFFS/JSRM International Meeting 2015
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ロボット支援下前立腺全摘除術施行患者における前立腺摘出重量別にみた排尿状態の検討2015

    • Author(s)
      濱川 隆、佐々木 昌一、窪田 泰江、戸澤 啓一、林 祐太郎、郡 健二郎
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢 他(石川県金沢市)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ロボット支援下前立腺全摘除術後の新たな尿失禁防止術の開発とその尿禁制機序の考案。2013

    • Author(s)
      窪田泰江
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      さっぽろ芸術文化の館(札幌)
    • Related Report
      2013 Research-status Report
  • [Presentation] Urinary stem cell factor level could be a novel diagnostic biomarker for benign prostatic hyperplasia patients with OAB.2013

    • Author(s)
      Kubota Yasue, Kojima Yoshiyuki, Imura Makoto, Shibata Yasuhiro, Hamakawa Takashi, Sasaki Shoichi, Kohri Kenjiro
    • Organizer
      American Urological Association Annual Meeting
    • Place of Presentation
      San Diego Convention Center( San Diego, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 過活動膀胱におけるSCF-Kitシグナル伝達系の機能解析と新しいバイオマーカーの開発。

    • Author(s)
      窪田泰江、佐々木昌一
    • Organizer
      第14回AKUA学術集会
    • Place of Presentation
      グランドプリンスホテル高輪(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] 高齢化社会における過活動膀胱治療およびバイオマーカー探索の現状。

    • Author(s)
      窪田泰江
    • Organizer
      第26回日本老年泌尿器科学会
    • Place of Presentation
      横浜産貿ホール(横浜)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 下部尿路機能障害に対する清心連子飲の有効性の検証。

    • Author(s)
      窪田泰江
    • Organizer
      第25回東洋医学に関する学術研究報告会
    • Place of Presentation
      名古屋市立大学薬学部(名古屋)
    • Related Report
      2013 Research-status Report
  • [Book] 今日の治療指針2014

    • Author(s)
      窪田 泰江
    • Total Pages
      2014
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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