Effective compounds for male infertility patients with reference data for a noninvasive genetic diagnosis
| Project/Area Number |
25462544
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Nagasaki International University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TSUJIMURA AKIRA 大阪大学, 大学院医学部, 准教授 (40294053)
MIYAGAWA YASUSHI 大阪大学, 大学院医学部, 准教授 (70362704)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | アンドロロジー / 男性不妊症 / 精子形成 / 精巣 / 人工授精 / 遺伝子 / 生薬 / 生殖細胞 / 一塩基多型 / 精子 / 受精 / 不妊症 / 甘草 / Licorice / Isoliquurutingenin / Herbal medicine / Flavonoid / Sperm / Fertilization / Egg / IVF |
|---|
| Outline of Final Research Achievements |
Our diagnostic approach enabled us to identify genetic factors in ≥10% of male infertility patients. Furthermore, we found that licorice, which is used as an herbal medicine, increased fertility in mice. In this study, we screened novel chemical substances for in vitro fertilization (IVF) effects using an animal model of male infertility with a specific haploid germ cell gene deficiency. We also analyzed the mechanism underlying the effect of licorice. As a result, we identified a novel peptide that restored fertilization by IVF in male infertile mice (manuscript in preparation). Isoliquiritigenin and formononetin were isolated from licorice as active compounds for IVF. These compounds did not introduce abnormalities in embryogenesis, and both were effective in embryogenesis after IVF in a cow. Our findings demonstrate that effective compounds can be offered to male infertility patients based on the results of a noninvasive genetic diagnosis.
|
Report
(3 results)
Research Products
(16 results)
-
-
-
-
[Journal Article] TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis2015
Author(s)
Matsubara Yohei, Kato Tomoko, Kashimada Kenichi, Tanaka Hiromitsu, Zhi Zhou, Ichinose Shizuko, Mizutani Shuki, Morio Tomohiro, Chiba Tomoki, Ito Yoshiaki, Saga Yumiko, Takada Shuji, and Asahara Hiroshi
-
Journal Title
Stem Cells and Development
Volume: 24
Issue: 10
Pages: 1164-1170
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.2015
Author(s)
Okuda H, Kiuchi H, Takao T, Miyagawa Y, Tsujimura A, Nonomura N, Miyata H, Okabe M, Ikawa M, Kawakami K, Goshima N, Wada M, Tanaka H.
-
Journal Title
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
