| Project/Area Number |
25462596
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
YASUI Toshiyuki 徳島大学, 大学院医歯薬学研究部, 教授 (40230205)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUI Sumika 徳島大学, 病院, 助教 (00622888)
IRAHARA Minoru 徳島大学, 大学院医歯薬学研究部, 教授 (20160070)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 周閉経期 / 脂質代謝 / 糖代謝 / 男性ホルモン / 脂質・糖代謝 / レプチン / 肝機能 / テストステロン / DHEA-S / スクレロスチン / アディポネクチン / ホルモン補充療法 |
|---|
| Outline of Final Research Achievements |
The role of androgen including testosterone and DHEA-S has not been clarified in women during the menopausal transition. Androgen such as free testosterone and bioavailable testosterone might be involved in changes in systolic blood pressure, diastolic blood pressure and circulating levels of triglyceride and HDL-C in women during the menopausal transition. Changes in adiponectin and leptin during the menopausal transition showed unique patterns, and testosterone was associated with these patterns of adiponectin and leptin. It has been suggested that decreases in DHEA-S levels in women who received oral and transdermal hormone replacement therapy for menopausal symptoms were involved in feedback mechanism of hypothalamus-pituitary-adrenal gland. Further studies for involvement of estrogen in hypothalamus-pituitary-adrenal with hypothalamus-pituitary-ovarian axis.
|
