Establishment of DMEK for bullous keratopahty and analysis of postoperative visual function

• Project/Area Number: 25462705
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kanazawa University
• Principal Investigator: Kobayashi Akira 金沢大学, 医学系, 講師 (20303274)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 角膜内皮移植 / DSEAK / DMEK / 角膜移植 / DSAEK / ＤＳＡＥＫ / ＤＭＥＫ

Outline of Final Research Achievements

In this experiment, most advanced form of corneal endothelaila keratoplasty, DMEK(Descemet’s Membrane Endothelial Keratoplasty), for Japanese eye was successfully established. DMEK provides fast visual recovery with high visual acuity. Also, DMEK has almost no immunological rejection. I have also successfully devloped original tools for DMEK. Additionally, I investigated in vivo postoperative microstructure of the cornea after DMEK.

Research Products

• [Journal Article] Evaluation of internationally shipped prestripped donor tissue for descemet membrane endothelial keratoplasty by vital dye staining. (2015)
  • Author(s): Kobayashi A, Murata N, Yokogawa H, Yamazaki N, Masaki T, Sugiyama K.
  • Journal Title: Cornea Volume: 34 Issue: 2 Pages: 225-227
  • DOI: 10.1097/ico.0000000000000330
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. (2015)
  • Author(s): Kobayashi A, Yokogawa H, Yamazaki N, Masaki T, Sugiyama K.
  • Journal Title: Clin Ophthalmol. Volume: 9 Pages: 91-93
  • DOI: 10.2147/opth.s74981
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vivo laser confocal microscopy after Descemet membrane endothelial keratoplasty. (2013)
  • Author(s): Kobayashi A, Yokogawa H, Yamazaki N, Masaki T, Sugiyama K
  • Journal Title: Ophthalmology Volume: 120 Issue: 5 Pages: 923-930
  • DOI: 10.1016/j.ophtha.2012.11.006
  • Peer Reviewed
• [Journal Article] Descemet's stripping and non-Descemet's stripping automated endothelial keratoplasty for microcornea using 6.0 mm donor grafts. (2013)
  • Author(s): Yokogawa H, Kobayashi A, Yamazaki N, Ueta Y, Hashimoto Y, Tachi N, Sugiyama K.
  • Journal Title: Ｃｌｉｎｉｃａｌ Ｏｐｈｔｈａｌｍｏｌｏｇｙ Volume: 7 Pages: 1951-1956
  • DOI: 10.2147/opth.s50299
  • Peer Reviewed
• [Presentation] Visualization of precut DSAEK and pre-stripped DMEK donor cornea by intraoperative SD-OCT (RESCAN 700) (2015)
  • Author(s): Kobayashi A, Yokogawa H, Mori N, Sugiyama K.
  • Organizer: American Academy of Ophthalmology 2015
  • Place of Presentation: Las Vegas, Nevada
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] DMEK for shallow chamber (2015)
  • Author(s): Kobayashi A
  • Organizer: Eukornea
  • Place of Presentation: Barcelona
  • Year and Date: 2015-09-05
  • Int'l Joint Research / Invited
• [Presentation] Vital dye staining evaluation of internationally shipped pre-stripped donor tissue for Descemet’s membrane endothelial keratoplasty. (2014)
  • Author(s): Kobayashi A. Murata N, Yokogawa H, Toshinori M, Sugiyama K.
  • Organizer: American Academy of Ophthalmology Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ
  • Place of Presentation: Chicago, Illinois (McCormick Place Convention Center)
  • Year and Date: 2014-10-20
• [Presentation] 角膜内皮移植の歴史とこれから
  • Author(s): 小林 顕
  • Organizer: あぼし眼科勉強会
  • Place of Presentation: 姫路市 ツカザキ病院
  • Invited
• [Presentation] 角膜内皮移植の（DSAEK/DMEK）の現状と今後の展望
  • Author(s): 小林 顕
  • Organizer: 第56回山口眼科手術懇話会
  • Place of Presentation: 宇部市 山口大学医学部霜仁会館
  • Invited
• [Presentation] 小林 顕 ｢角膜内皮移植の（PKP/DALK/DSAEK/DMEK）の習得法・教育法における私の工夫
  • Author(s): 小林 顕
  • Organizer: 瀬戸内眼科コロシアム2013
  • Place of Presentation: 広島市 シェラトンホテル広島
  • Invited