| Project/Area Number |
25462717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOTTA Fumika 徳島大学, 病院, 医員 (80645838)
EGAWA Mariko 徳島大学, 大学院医歯薬学研究部, 講師 (70507657)
MINO Akiko 徳島大学, 病院, 助教 (50531836)
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| Co-Investigator(Renkei-kenkyūsha) |
HARADA Takayuki 公益財団法人東京都医学総合研究所, 視覚病態プロジェクト, 副参事研究員 (90345306)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 外科 / 細胞・組織 / 生体分子 / 糖尿病 / 臨床 |
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| Outline of Final Research Achievements |
Peroxisome proliferator-activated receptor gamma (PPARγ) was detected in the exosome fraction of the culture media of human umbilical vein endothelial cells, indicating that PPARγ, a nuclear protein, can be released into the extracellular fluid. PPARγ mRNA expression levels in membrane samples, and the PPARγprotein concentrations in aqueous humor and vitreous fluid samples were significantly higher in patients with proliferative diabetic retinopathy (PDR) than control patients. We observed a significant positive correlation between the PPARγlevels and vascular endothelial growth factor levels or clinical stage of retinopathy in the aqueous humor and vitreous fluid of PDR patients. Taken together, PPARγ may be a therapeutic target for diabetic retinopathy.
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