| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Using gene knockout mice, we studied biological function of latent TGR-beta binding protein-2 (LTBP-2) and found the mutant mice develop lens dislocation due to malformation of ciliary zonules, which anchors lens to ciliary bodies in the eye. Since mutations of LTBP2, a gene encoding LTBP-2, have been found on patients of inherited eye diseases, such as primary congenital glaucoma and ectopia lentis, we analyzed any phenotypes related to glaucoma in the mutant mice. We observed LTBP-2-deficent DBA2 mice show higher intraocular pressure compared to wild type mice, but this phenotype was not observed in B6 strain. These results indicated that LTBP-2 deficient mice will be one of the model animals for analysis of human ocular diseases.
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