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the role of versican in skin and wound healing

Research Project

Project/Area Number 25462801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionKeio University

Principal Investigator

Aramaki Noriko  慶應義塾大学, 医学部(信濃町), 講師 (80365311)

Co-Investigator(Kenkyū-buntansha) 貴志 和生  慶應義塾大学, 医学部(信濃町), 教授 (40224919)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsversican / wound healing / scarless wound / versikine / 血管新生 / 創傷治癒 / 細胞外マトリックス / vesican / 皮膚
Outline of Final Research Achievements

In a wound-healing model using Vcanhdf/+ mice, we found that neovascularization is more strongly suppressed in Vcanhdf/+ mice than WT mice.This same phenomenon was observed using the cancer model in this study, suggesting that versican may have an important role in neovascularization. In the future, we plan to conduct functional analyses of versican on neovascularization.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (9 results)

  • [Journal Article] ケロイドにおけるversikine-SHAP-ヒアルロン酸複合体の病態関与への可能 性。2015

    • Author(s)
      荒牧典子、村澤裕介、磯貝善蔵、岡部圭介、貴志和生
    • Journal Title

      瘢痕・ケロイド治療ジャーナル

      Volume: 9 Pages: 54-57

    • Related Report
      2015 Research-status Report
  • [Journal Article] 細胞外マトリックスから見たケロイド2014

    • Author(s)
      荒牧典子、磯貝善蔵、岡部圭介、貴志和生
    • Journal Title

      日本創傷外科学会会誌「創傷」

      Volume: 5(2) Pages: 51-55

    • NAID

      130004553026

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ケロイドと飛行性瘢痕におけるAdamts(a disintegrin-like and metalloprotease with thrombospondin type 1 motif)の発現検討2014

    • Author(s)
      荒牧典子、磯貝善蔵、岡部圭介、林瑠加、貴志和生
    • Journal Title

      瘢痕・ケロイド治療ジャーナル

      Volume: 8 Pages: 43-45

    • Related Report
      2014 Research-status Report
  • [Journal Article] A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression2014

    • Author(s)
      Dubail J*, Aramaki-Hattori N *, Bader HL, Nelson CM, Katebi N, Matuska B, Olsen BR, Apte SS
    • Journal Title

      Genesis

      Volume: 52(7) Issue: 7 Pages: 702-712

    • DOI

      10.1002/dvg.22784

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 毛乳頭におけるversikineの役割2016

    • Author(s)
      荒牧典子、Apte Suneel、岡部圭介、酒井成貴、岡田保典、貴志和生
    • Organizer
      第46回日本創傷治癒学会
    • Place of Presentation
      伊藤国際学術研究センター/安田行動(東京都文京区)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] ケロイド組織のホールマウント染色による血管・神経可視化の試み2016

    • Author(s)
      岡部圭介、荒牧典子、酒井成貴、貴志和生
    • Organizer
      第25回日本形成外科学会基礎学術集会
    • Place of Presentation
      ナレッジキャピタル コングレ・コンベンションセンター(大阪府大阪市)
    • Year and Date
      2016-04-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 毛包を含めた皮膚の完全再生2016

    • Author(s)
      貴志和生、岡部圭介、荒牧典子、酒井成貴
    • Organizer
      第25回日本形成外科学会基礎学術集会
    • Place of Presentation
      ナレッジキャピタル コングレ・コンベンションセンター(大阪府大阪市)
    • Year and Date
      2016-04-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] ケロイドにおけるversican2015

    • Author(s)
      荒牧典子、高戸珠恵、岡部圭介、貴志和生
    • Organizer
      第45回日本創傷治癒学会
    • Place of Presentation
      JPタワーホール&カンファレンス(東京都千代田区)
    • Year and Date
      2015-11-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞外マトリックスversicanの分解産物であるversikineのケロイド病態関与への可能性2014

    • Author(s)
      荒牧典子、村澤裕介、磯貝善蔵、岡部圭介、貴志和生
    • Organizer
      第23回日本形成外科学会基礎学術集会
    • Place of Presentation
      長野
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ケロイドにおける versikine-SHAP-ヒアルロン酸複合体䛾病態関与への可 能性2014

    • Author(s)
      荒牧典子、村澤裕介、磯貝善蔵、岡部圭介、貴志和生
    • Organizer
      第9回瘢痕ケロイド治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Reduced ADAMTS5 proteolysis of versican is associated with accumulation of pericellular matrix in fibroblasts and transition to a myofibroblastic phenotype2013

    • Author(s)
      Noriko Aramaki-Hattori
    • Organizer
      Tissue Repair and Regeneration: Gordon research conferences
    • Place of Presentation
      New London, NH, United states
    • Related Report
      2013 Research-status Report
  • [Presentation] 次世代のケロイド・肥厚性瘢痕治療:細胞外マトリックスから見た ケロイド-ケロイド組織におけるversicanの産生・分解2013

    • Author(s)
      荒牧典子
    • Organizer
      第15回日本創傷外科学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] ケロイド組織におけるversikineの役割2013

    • Author(s)
      荒牧典子
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      新潟
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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