| Project/Area Number |
25462844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | National Defense Medical College |
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Principal Investigator |
SAITOH Diazoh 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 教授 (90531632)
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| Co-Investigator(Kenkyū-buntansha) |
武岡 真司 早稲田大学, 理工学術院, 教授 (20222094)
小野 聡 東京医科大学, 医学部, 教授 (30531355)
宮崎 裕美 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 助教 (30531636)
木下 学 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (70531391)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 熱傷 / マイクロスキン / ナノシート / 感染制御 / 創傷被覆材 / 血管新生 / 創傷治癒 / 機能性ナノシート / 抗菌性 / 抗菌能 / 同種皮膚 / 上皮化 |
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| Outline of Final Research Achievements |
Microskin grafting can be expanded more than 10-fold by mincing the skin grafts, and is an effective
method for the treatment of extensive burn injury. We recently fabricated biodegradable ultra-thin nanosheets, which have advantageous properties for their application as a wound dressing, such as transparency, tight adherence, and moisture permeability. This study aimed to investigate the efficacy of a microskin grafts (MSG) combined with nanosheets (NS) in the wound healing using burn wound models in mice. Treatment of the burn wounds with MSG/NS significantly accelerated the wound healing compared with non-treatment, characterized by an increased rate of re-epithelialization and remodeling. In addition, MSG/NS also enhanced platelet-derived growth factor expression and vascular networks of the wound bed in the early stages of repair. In conclusion, microskin grafting and nanosheets might be a possible new and effective procedure for repairing extensive burn wounds.
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