| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Periodontal disease is caused by multi-species of bacteria colonizing the periodontal tissues. Some species directly adhere to the gingival epithelial cells, but the mechanism is not well understood. Periodontitis-associated bacteria generally grow in an oxygen-free (anaerobic) environment. However, studies on adhesion to gingival epithelial cells have been performed under aerobic conditions. Therefore, in this study, it was conducted to establish a method of the infection experiment under anaerobic conditions. In addition, several strains of periodontitis-associated and anaerobic bacterium Treponema denticola were comparatively analyzed for some typical pathogenicities including adhesive activity to the gingival epithelia.
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