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Anti-inflammatory effect of MMP-3 on tissue regeneration in dental pulpitis.

Research Project

Project/Area Number 25462882
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Morphological basic dentistry
Research InstitutionKanazawa University

Principal Investigator

nakamura hiroyuki  金沢大学, 医学系, 准教授 (30542253)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯髄炎 / MMP-3 / MMP / バーシカン
Outline of Final Research Achievements

In this study, to clear the mechanism of the effect of MMP-3 as anti-pulpitis drugs, we identified the MMP-3 binding protein in human dental pulp tissues. From results of analyses, versican was identified as substrate of MMP-3. On canine pulpitis model, structure and localization of versican on MMP-3 treated pulp tissue was different to control non treated tissues. In conclusion, complex of versican and hyaluronic acid was critical in recruiting of inflammatory cells, and anti-inflammatory effects of MMP-3 were closely linked to disruption of versican and hyaluronic acid.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

Research Products

(11 results)

All 2016 2014 2013

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2016

    • Author(s)
      Ito Kimura, Hiroko Kitahara, Kazuhiro Ooi, Koroku Kato, Natsuyo Noguchi, Kunio Yoshizawa, Hiroyuki Nakamura, Shuichi Kawashiri
    • Journal Title

      Oncol Lett

      Volume: 11 Pages: 201-207

    • DOI

      10.3892/ol.2015.3833

    • NAID

      120005973602

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Generation of a mouse line harboring a bi-transgene expressing luciferase and tamoxifen-activatable creERT2 recombinase in cartilage2014

    • Author(s)
      Leandro Lo Cascio, Ke Liu, Hiro Nakamura, Grace Chu, Ngee Han Lim, Anastasios Chanalaris, Jeremy Saklatvala, Hideaki Nagase andGeorge Bou-Gharios
    • Journal Title

      genesis

      Volume: 52 Pages: 110-119

    • DOI

      10.1002/dvg.22734

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prognostic value of vascular endothelial growth factor A and C in oral squamous cell carcinoma2014

    • Author(s)
      Yanase M., Kato K., Yoshizawa K., Noguchi N., Kitahara H., Nakamura H
    • Journal Title

      Journal of Oral Pathology and Medicine

      Volume: (in press) Pages: 514-20

    • DOI

      10.1111/jop.12167

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 口腔扁平上皮癌におけるEGFR発現と浸潤様式の相関と上皮間葉移行の関与2016

    • Author(s)
      中村博幸、川尻秀一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Loss of EGFR expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2016

    • Author(s)
      Hiroyuki Nakamura, Iyo Kimura, Hiroko Kitahara, Shuichi Kawashiri;
    • Organizer
      European Cancer Congress 2015
    • Place of Presentation
      Vienna.
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規加工コラーゲンによる骨造成効果の検討2016

    • Author(s)
      定梶嶺、中村博幸、川尻秀一
    • Organizer
      第45回日本口腔インプラント学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2016-09-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Loss of EGFR expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition2016

    • Author(s)
      Iyo Kimura, Hiroko Kitahara, Hiroyuki Nakamura, Shuichi Kawashiri;
    • Organizer
      The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology (ASHNO) and 39th Annual Meeting of Japan Society for Head and Neck Cancer (JSHNC)
    • Place of Presentation
      kobe
    • Year and Date
      2016-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顎関節症滑膜炎におけるエラスチン分解産物の役割2016

    • Author(s)
      中村博幸、小林一彦、田中彰、高塚茂之、川尻秀一
    • Organizer
      第47回日本結合組織学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯髄炎でのMMP-3の抗炎症、組織再生作用とバーシカンの役割2014

    • Author(s)
      中村博幸、村澤裕介、平真優子、小林一彦、磯貝善蔵、川尻秀一
    • Organizer
      第46回日本結合組織学術大会
    • Place of Presentation
      愛知 ウインクあいち
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 不可逆性歯髄炎でのMMP-3の抗炎症、組織再生作用のメカニズム解析2013

    • Author(s)
      中村博幸
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] MMP-3の抗炎症、組織再生作用の検討2013

    • Author(s)
      中村博幸、川尻秀一
    • Organizer
      第58回日本口腔外科学会学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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