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Thrapeutic effects of biotin on allergic dermatitis through Th balance modulation

Research Project

Project/Area Number 25462913
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

Kuroishi Toshinobu  東北大学, 歯学研究科(研究院), 助教 (30400261)

Co-Investigator(Kenkyū-buntansha) SUGAWARA SHUNJI  東北大学, 大学院歯学研究科, 教授 (10241639)
TANAKA YUKINORI  東北大学, 大学院歯学研究科, JSPS特別研究員(PD) (60637958)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsビオチン / アトピー性皮膚炎 / 接触性過敏症 / メタボローム解析 / 代謝異常 / Thバランス / 接触性皮膚炎
Outline of Final Research Achievements

Biotin is a water-soluble B complex vitamin and functions as a co-factor of five indispensable carboxylases in cells. It was reported that serum biotin concentrations are significantly lower in atopic dermatitis patients. In this study, we investigated the effects of biotin intake on atopic dermatitis by using mouse model. However, no significant differences were detected in symptoms of atopic dermatitis between biotin-deficient and biotin-sufficient mice.
On the other hand, concentrations of several amino acids, such as methionine and cysteine were significantly lower in liver taken from biotin-deficient mice than biotin-sufficient mice. Moreover, anti-oxidant capacities were significantly lower in biotin-deficient cells than biotin-sufficient cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] ビオチン依存性カルボキシラーゼによるTh17分化の制御2016

    • Author(s)
      黒石智誠
    • Journal Title

      ビタミン

      Volume: 90 Pages: 122-125

    • NAID

      110010043285

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of Immunological and Inflammatory Functions bi Biotin2015

    • Author(s)
      Toshinobu Kuroishi
    • Journal Title

      Canadian Journal of Physiology and Pharmacology

      Volume: 印刷中 Issue: 12 Pages: 1091-1096

    • DOI

      10.1139/cjpp-2014-0460

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ビオチンによる代謝制御と遺伝子発現制御2015

    • Author(s)
      黒石智誠
    • Organizer
      第26回フォーラム・イン・ドージン
    • Place of Presentation
      熊本県熊本市 熊本ホテルキャッスル
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ビオチン欠乏に伴うアミノ酸代謝異常と抗酸化能の低下2015

    • Author(s)
      黒石智誠、菅原俊二
    • Organizer
      日本ビタミン学会第67回大会
    • Place of Presentation
      奈良県奈良市 奈良春日野国際フォーラム
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ビオチン欠乏マウスにおける表皮免疫担当細胞の解析2014

    • Author(s)
      黒石智誠、田中志典、遠藤康男、菅原俊二
    • Organizer
      日本ビタミン学会
    • Place of Presentation
      兵庫県姫路市 姫路商工会議所
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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